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. 2021 Mar;17(3):150-154.
doi: 10.1016/j.reuma.2019.04.006. Epub 2019 Jun 27.

Epidemiological Characteristics and Adverse Events of Patients with Psoriatic Arthritis Undergoing Treatment with Biological Therapies in Galicia

[Article in English, Spanish]
Carlos García Porrúa  1 , Francisco José Maceiras Pan  2 , José Antonio Mosquera Martínez  3 , Loreto Carmona  4 , Blanca Correa Rey  5 , Luis Fernández Domínguez  6 , María Noelia Álvarez Rivas  7 , José Antonio Pinto Tasende  8
Affiliations
Free article

Epidemiological Characteristics and Adverse Events of Patients with Psoriatic Arthritis Undergoing Treatment with Biological Therapies in Galicia

[Article in English, Spanish]
Carlos García Porrúa et al. Reumatol Clin (Engl Ed). 2021 Mar.
Free article

Abstract

Patients with severe forms of psoriatic arthritis (PsA) usually require treatment with biological agents. A greater knowledge of this subgroup of patients and their treatment enables better decision making in real clinical practice.

Methods: Longitudinal, multicentric observational study. We included all patients older than 16 years diagnosed with PsA in treatment with biological therapies from January 1, 2011 to December 31, 2015 treated in 6 Galician hospitals.

Results: Six hundred and fourpatients with PsA received biological therapies. Etanercept was the most used biological treatment. The average time of follow-up was 2.5 years and 67.9% were being treated with the first biological treatment. They were mostly patients with the peripheral subtype and met the criteria for clinical remission. Thirty-two percent had positive HLA-B27 and it was associated with axial PA subtypes. The prevalence of tuberculosis treated previously was 5.9%, and 23% of patients received chemoprophylaxis for latent tuberculosis. Twenty-four patients had undergone a prosthetic replacement. Hip prosthesis was the most frequent. Ninety-nine cases were treated for affective disorders. A diagnosis of fibromyalgia was established in 11 cases mostly women. Of the cases, 6.6% had episodes of serious infections, with respiratory infections being the most frequent. Sixteen tumours were detected (2.9%). Prostate cancer and gynaecological tumours were the most frequent. As with infections, the greater the age the greater the risk of presenting a tumour.

Conclusions: We describe the epidemiological and safety characteristics in real life of a Galician multicentre cohort of patients with psoriatic arthritis under biological treatment.

Keywords: Artritis psoriásica; Biological therapies; Clinical practice; Epidemiology; Epidemiología; Práctica clínica; Psoriatic arthritis; Terapias biológicas.

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