Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Mar 15;105(3):266-70.
doi: 10.1016/0002-9394(88)90008-6.

Recombinant tissue plasminogen activator to lyse experimentally induced retinal arterial thrombi

A K Vine  1 , P T Maguire, C Martonyi, M C Kincaid
Affiliations

Recombinant tissue plasminogen activator to lyse experimentally induced retinal arterial thrombi

A K Vine et al. Am J Ophthalmol. .

Abstract

We evaluated the efficacy of intravenously administered recombinant tissue plasminogen activator to lyse laser-induced arterial thrombi in the stroke-prone, spontaneously hypertensive rat model. The arterial thrombi were confirmed histologically, and assessed by color photographs and fluorescein angiography before and after intravenous tissue plasminogen activator or saline therapy. Experimental animals received tissue plasminogen activator (1 mg/kg of body weight) given intravenously over one hour, and control animals received similar volumes of normal saline. Tissue plasminogen activator was effective in lysing experimental retinal arterial thrombi.

PubMed Disclaimer

Publication types

LinkOut - more resources