What Is Excitation/Inhibition and How Is It Regulated? A Case of the Elephant and the Wisemen
- PMID: 31258334
- PMCID: PMC6591655
- DOI: 10.1177/1179069519859371
What Is Excitation/Inhibition and How Is It Regulated? A Case of the Elephant and the Wisemen
Abstract
The balance between excitation and inhibition in neuronal circuits has drawn more and more attention in recent years, due to its proposed multifaceted functions in the normal neural circuit as well as its potential roles in the etiology of many neurological disorders. Here, we discuss the importance of clearly defining excitation/inhibition by experimental measurements and the implications of some recent studies to our understanding of the regulation of excitation/inhibition at the neuronal level.
Keywords: Excitation/inhibition balance; circuit dysfunction; intrinsic excitability; sensory-evoked synaptic current; spontaneous synaptic current.
Conflict of interest statement
Declaration of conflicting interests:The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Comment on
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Excitatory synaptic dysfunction cell-autonomously decreases inhibitory inputs and disrupts structural and functional plasticity.Nat Commun. 2018 Jul 24;9(1):2893. doi: 10.1038/s41467-018-05125-4. Nat Commun. 2018. PMID: 30042473 Free PMC article.
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