Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2019 Jun 20:12:1179547619854703.
doi: 10.1177/1179547619854703. eCollection 2019.

Long-term Survival in a Case of Renal Cell Carcinoma With Brain Metastases: A Case Report

Affiliations
Case Reports

Long-term Survival in a Case of Renal Cell Carcinoma With Brain Metastases: A Case Report

Ginil Kumar Pooleri et al. Clin Med Insights Case Rep. .

Abstract

Renal cell carcinoma with brain metastases is considered to have a poor prognosis. We are reporting a case of a 63-year-old male who showed excellent long term remission with a combination treatment of radiation and tyrosine kinase inhibitor for a solitary lesion in the brain, secondary to the renal tumor.

Keywords: Brain metastases; Renal cell carcinoma; Tyrosine kinase inhibitor.

PubMed Disclaimer

Conflict of interest statement

Declaration of conflicting interests:The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
(A) MRI lesion in brain and (B) MRI lesion responding completely to TKI. MRI indicates magnetic resonance imaging; TKI, tyrosine kinase inhibitor.
Figure 2.
Figure 2.
(A) Kidney tumour before staring TKI and (B) primary tumour after TKI. TKI indicates tyrosine kinase inhibitor.

References

    1. Wyler L, Napoli CU, Ingold B, et al. Brain metastasis in renal cancer patients: metastatic pattern, tumour-associated macrophages and chemokine/chemoreceptor expression. Br J Cancer. 2014;110:686–694. doi:10.1038/bjc.2013.755. - DOI - PMC - PubMed
    1. Dudek AZ, Raza A, Chi M, et al. Brain metastases from renal cell carcinoma in the era of TKI. Clin Genitourin Cancer. 2013;11:155–160. - PMC - PubMed
    1. Yu CC, Ou YC, Ho HC, Cheng CL, Li JR. Treatment of metastatic carcinoma to the brain: a report of long term survival following multimodal treatment and sequential use of targeted agents. Urol Sci. 2014;25:119–121.
    1. Scuch B, Rochelle JCL, Klatte T, et al. Brain metastses from renal carcinoma. Cancer. 2008;113:1641–1648. - PubMed
    1. Escudier B, Eisen T, Stadler WM, et al. Sorafenib in advanced clear-cell renal cell carcinoma. N Engl J Med. 2007;356:125–134. - PubMed

Publication types

LinkOut - more resources