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Review
. 2019 Jun 21:12:1756286419857040.
doi: 10.1177/1756286419857040. eCollection 2019.

Non-invasive ventilation in amyotrophic lateral sclerosis

Johannes Dorst  1 , Albert C Ludolph  1
Affiliations
Review

Non-invasive ventilation in amyotrophic lateral sclerosis

Johannes Dorst et al. Ther Adv Neurol Disord. .

Abstract

Non-invasive ventilation (NIV) has become an important cornerstone of symptomatic treatment in amyotrophic lateral sclerosis (ALS), improving survival and quality of life. In this review, we summarize the most important recent developments and insights, including evidence of efficacy, indication criteria and time of initiation, ventilation parameters and adaptation strategies, treatment of complicating factors, transition from NIV to invasive ventilation, termination of NIV and end-of-life management. Recent publications have questioned former conventions and guideline recommendations, especially with regard to timing and prognostic factors; therefore, a fresh look and re-evaluation of current evidence is needed.

Keywords: amyotrophic lateral sclerosis; motor neuron diseases; non-invasive ventilation.

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Conflict of interest statement

Conflict of interest statement: The authors declare that there is no conflict of interest.

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