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. 2019 Jun 28;8(7):940.
doi: 10.3390/jcm8070940.

Combined Intervention of Physical Activity, Aerobic Exercise, and Cognitive Exercise Intervention to Prevent Cognitive Decline for Patients with Mild Cognitive Impairment: A Randomized Controlled Clinical Study

Hyuntae Park  1   2 , Jong Hwan Park  3 , Hae Ri Na  4 , Shimada Hiroyuki  2 , Gwon Min Kim  1 , Min Ki Jung  1 , Woo Kyung Kim  5 , Kyung Won Park  5   6
Affiliations

Combined Intervention of Physical Activity, Aerobic Exercise, and Cognitive Exercise Intervention to Prevent Cognitive Decline for Patients with Mild Cognitive Impairment: A Randomized Controlled Clinical Study

Hyuntae Park et al. J Clin Med. .

Abstract

This study aimed to investigate the association between a dual-task intervention program and cognitive and physical functions. In a randomized controlled trial, we enrolled 49 individuals with MCI. The MCI diagnosis was based on medical evaluations through a clinical interview conducted by a dementia specialist. Cognitive assessments were performed by neuropsychologists according to standardized methods, including the MMSE and modified Alzheimer's disease Assessment Scale-Cognitive Subscale (ADAS-Cog), both at baseline and at 3 months follow-up. The program comprised physical activity and behavior modification, aerobic exercise, and a cognitive and exercise combined intervention program. Analysis of the subjects for group-time interactions revealed that the exercise group exhibited a significantly improved ADAS-Cog, working memory, and executive function. Total physical activity levels were associated with improvements in working memory function and the modified ADAS-Cog score, and the associations were stronger for daily moderate intensity activity than for daily step count. The 24-week combined intervention improved cognitive function and physical function in patients with MCI relative to controls. Encouraging participants to perform an additional 10 min of moderate physical activity under supervision, during ongoing intervention, may be more beneficial to prevent cognitive decline and improve exercise adherence.

Keywords: dementia; dual-task; older adults; randomized controlled trial.

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Conflict of interest statement

Funding: This research was funded by the Dong-A University research grant.

Figures

Figure 1
Figure 1
Subject flow diagram from initial contact through to study completion.
Figure 2
Figure 2
Change in cognitive performance during the 24 week intervention. Mean change in modified the Alzheimer’s Disease Assessment Scale-Cognitive Subscale ADAS-Cog score from baseline (negative differences correspond to lower scores, indicating performance improvement). Error bars are SEM; p-value (p < 0.05) from mixed-model repeated measure analysis, group × time interaction. * p < 0.05.
Figure 3
Figure 3
Changes in averaged daily moderate to vigorous physical activity during the intervention period. Black and gray lines show curve-fitting in both linear and exponential fit and 95% confidence band. Both groups wore waist-mounted accelerometers during the intervention period.
See this image and copyright information in PMC

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