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. 2019 Jun 29;24(13):2412.
doi: 10.3390/molecules24132412.

Euphosantianane E-G: Three New Premyrsinane Type Diterpenoids from Euphorbia sanctae-catharinae with Contribution to Chemotaxonomy

Abdelsamed I Elshamy  1 , Tarik A Mohamed  2 , Saud L Al-Rowaily  3 , Ahmed M Abd-ElGawad  3   4 , Basharat A Dar  3 , Abdelaaty A Shahat  2   5 , Mohamed-Elamir F Hegazy  6   7
Affiliations

Euphosantianane E-G: Three New Premyrsinane Type Diterpenoids from Euphorbia sanctae-catharinae with Contribution to Chemotaxonomy

Abdelsamed I Elshamy et al. Molecules. .

Abstract

Euphorbia species were widely used in traditional medicines for the treatment of several diseases. From the aerial parts of Egyptian endemic plant, Euphorbia sanctae-catharinae, three new premyrsinane diterpenoids, namely, euphosantianane E-G (1-3), alongside four known triterpenes, 9,19-cyclolanostane-3β,24S-diol (4), 25-methoxycycloartane-3β,24S-diol (5), 25-methylenecycloartan-3β,24R-diol (6), and 25-methylenecycloartan-3β,24S-diol (7), were isolated and identified. The chemical structures were proven depending upon spectroscopic analysis, including FTIR, HRFABMS, and 1D/2D-NMR. The chemotaxonomic significance of the isolated compounds, especially diterpenes from E. sanctae-catharinae compared to those documented from different Euphorbia species was also studied via agglomerative hierarchical clustering (AHC). The Egyptian endemic Euphorbia sanctae-catharina was grouped with E. bupleuroides, E. fidjiana, E. fischeriana, E. pithyusa subsp. cupanii, E. prolifera, and E. seguieriana, where myrsinol diterpenoids were the characteristic compounds.

Keywords: Euphorbia sanctae-catharinae; chemotaxonomic significance; endemic plant; euphorbiaceae; euphosantianane E–G; premyrsinane diterpenoids.

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Conflict of interest statement

The authors declare that there is no conflict of interest.

Figures

Figure 1
Figure 1
Isolated compounds from Euphorbia sanctae-catharinae.
Figure 2
Figure 2
Selected significant 1H 1H COSY, and Key HMBC correlations of 1–3.
Figure 3
Figure 3
Significant NOESY correlations of 1–3.
Figure 4
Figure 4
Agglomerative hierarchical clustering (AHC) of 32 Euphorbia species and the present studied endemic Euphorbia (E. sanctae-catharinae) based on the terpenoid compounds.
See this image and copyright information in PMC

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