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Comment
. 2019 Jul;9(7):828-830.
doi: 10.1158/2159-8290.CD-19-0527.

Predictive Potential of Head and Neck Squamous Cell Carcinoma Organoids

Sarah J Hill  1   2 , Alan D D'Andrea  3   2   4
Affiliations
Comment

Predictive Potential of Head and Neck Squamous Cell Carcinoma Organoids

Sarah J Hill et al. Cancer Discov. 2019 Jul.

Abstract

In this issue of Cancer Discovery, Driehuis and colleagues establish culture conditions for the rapid, efficient, and long-term expansion of healthy human oral mucosa and head and neck squamous cell carcinoma (HNSCC) tumor organoids. The HNSCC tumor organoids provide a functional platform for analyzing tumor cell phenotype, tumorigenic potential, and drug and radiotherapy response, and they have a potential role in clinical decision-making.See related article by Driehuis et al., p. 852.

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  • Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy.
    Driehuis E, Kolders S, Spelier S, Lõhmussaar K, Willems SM, Devriese LA, de Bree R, de Ruiter EJ, Korving J, Begthel H, van Es JH, Geurts V, He GW, van Jaarsveld RH, Oka R, Muraro MJ, Vivié J, Zandvliet MMJM, Hendrickx APA, Iakobachvili N, Sridevi P, Kranenburg O, van Boxtel R, Kops GJPL, Tuveson DA, Peters PJ, van Oudenaarden A, Clevers H. Driehuis E, et al. Cancer Discov. 2019 Jul;9(7):852-871. doi: 10.1158/2159-8290.CD-18-1522. Epub 2019 May 3. Cancer Discov. 2019. PMID: 31053628

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