Opioid use disorder is associated with increased mortality and morbidity in patients with gastroparesis
- PMID: 31263359
- PMCID: PMC6595927
- DOI: 10.20524/aog.2019.0389
Opioid use disorder is associated with increased mortality and morbidity in patients with gastroparesis
Abstract
Background: Opioid use disorder (OUD) epidemic has been declared a nationwide public health emergency by the Department of Health and Human Services. There are limited data regarding OUD in patients with gastroparesis. This study aimed to evaluate the impact of OUD on the outcomes in patients hospitalized with gastroparesis and to delineate the trends associated with OUD and gastroparesis using a nationally representative sample.
Methods: We used the National (Nationwide) Inpatient Sample database from 2005-2014 to identify patients hospitalized with a primary diagnosis of gastroparesis (ICD 9 Code: 536.3) and a concurrent diagnosis of OUD. We used Pearson chi-square analysis to compare demographics, the independent samples t-test to assess differences in length of stay and cost of care, and multivariate regression analysis to adjust for confounders.
Results: Between 2005 and 2014, a total of 145,700 patients with a primary diagnosis of gastroparesis were hospitalized in the United States, of whom 4519 (3.1%) had a concurrent diagnosis of OUD. The prevalence of OUD in gastroparesis doubled from 2.1% in 2005 to 4.3% in 2014. After adjusting for confounders, patients with OUD had greater in-hospital mortality (adjusted odds ratio 2.7, 95% confidence interval: 2.1-3.5). Patients with OUD also had significantly longer hospital stays and higher costs. Independent predictors of OUD in patients with gastroparesis were younger age, female sex, alcohol use, depression, and Medicaid insurance.
Conclusion: OUD in patients with gastroparesis is associated with greater mortality and healthcare resource utilization.
Keywords: Gastroparesis; healthcare cost and utilization project; national inpatient sample database; opioid use disorder.
Conflict of interest statement
Conflict of Interest: None
Figures
Similar articles
-
Characteristics of Hospitalized Adults with Opioid Use Disorder in the United States: Nationwide Inpatient Sample.Pain Physician. 2021 Aug;24(5):327-334. Pain Physician. 2021. PMID: 34323434
-
Opioid use disorder among hospitalized adults in North Carolina: Comparative analysis of national and statewide trends.J Opioid Manag. 2021 Jul-Aug;17(4):343-352. doi: 10.5055/jom.2021.0667. J Opioid Manag. 2021. PMID: 34533829
-
Preexisting opioid use disorder is associated with poor outcomes in hospitalized acute pancreatitis patients.Eur J Gastroenterol Hepatol. 2021 Nov 1;33(11):1348-1353. doi: 10.1097/MEG.0000000000002265. Eur J Gastroenterol Hepatol. 2021. PMID: 34402465
-
Rising Prevalence of Opioid Use Disorder and Predictors for Opioid Use Disorder Among Hospitalized Patients With Chronic Pancreatitis.Pancreas. 2019 Nov/Dec;48(10):1386-1392. doi: 10.1097/MPA.0000000000001430. Pancreas. 2019. PMID: 31688606
-
Hospital Inpatient Stays Related to Opioid Use Disorder and Endocarditis, 2016.2020 Apr 14. In: Healthcare Cost and Utilization Project (HCUP) Statistical Briefs [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2006 Feb–. Statistical Brief #256. 2020 Apr 14. In: Healthcare Cost and Utilization Project (HCUP) Statistical Briefs [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2006 Feb–. Statistical Brief #256. PMID: 32479042 Free Books & Documents. Review.
Cited by
-
Working towards an ERAS Protocol for Pancreatic Transplantation: A Narrative Review.J Clin Med. 2021 Apr 1;10(7):1418. doi: 10.3390/jcm10071418. J Clin Med. 2021. PMID: 33915899 Free PMC article. Review.
References
-
- Khoo J, Rayner CK, Jones KL, Horowitz M. Pathophysiology and management of gastroparesis. Expert Rev Gastroenterol Hepatol. 2009;3:167–181. - PubMed
-
- Tack J, Carbone F, Rotondo A. Gastroparesis. Curr Opin Gastroenterol. 2015;31:499–505. - PubMed
-
- Revicki DA, Rentz AM, Dubois D, et al. Gastroparesis Cardinal Symptom Index (GCSI):development and validation of a patient reported assessment of severity of gastroparesis symptoms. Qual Life Res. 2004;13:833–844. - PubMed
LinkOut - more resources
Full Text Sources