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Review
. 2019 Jun 13:9:515.
doi: 10.3389/fonc.2019.00515. eCollection 2019.

Non-coding RNAs in Natural Killer/T-Cell Lymphoma

Mei Mei  1   2 , Mingzhi Zhang  1
Affiliations
Review

Non-coding RNAs in Natural Killer/T-Cell Lymphoma

Mei Mei et al. Front Oncol. .

Abstract

Natural killer/T-cell lymphoma (NKTCL) is a rare and aggressive subtype of non-Hodgkin's lymphoma that is associated with a poor outcome. Non-coding RNAs (ncRNAs), which account for 98% of human RNAs, lack the function of encoding proteins but instead have the important function of regulating gene expression, including transcription, translation, RNA splicing, editing, and turnover. However, the roles and mechanisms of aberrantly expressed ncRNAs in NKTCL are not fully clear. Aberrant expressions of microRNA (miRNAs) affect the PI3K/AKT signaling pathways (miRNA-21, miRNA-155, miRNA-150, miRNA-142, miRNA-494), NF-κB (miRNA-146a, miRNA-155) and cell cycle signaling pathways to regulate cell function. Moreover, Epstein-Barr virus (EBV) encoded miRNAs and EBV oncoprotein LMP-1 regulated the expression of cellular genes that induce invasion, metastasis, cell cycle progression and cellular transformation. In addition, NKTCL-associated Long non-coding RNA (lncRNA) ZFAS1 regulated certain pathways and lncRNA MALAT1 acted as a predictive marker. This review article provides an overview of ncRNAs associated with NKTCL, summarizes the function of significantly differentially expressed hotspot non-coding RNAs that contribute to the pathogenesis, diagnoses, treatment and prognosis of NKTCL and discusses the relevance of these ncRNAs to clinical practice.

Keywords: EBV-encoded miRNAs; lncRNAs; microRNAs; natural killer/T-cell lymphoma (NKTCL); non-coding RNAs.

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Figures

Figure 1
Figure 1
The PI3K/AKT and cell cycle signaling pathway model of NKTCL. MiRNAs can influence almost every cellular behavior from transcription to translation by diverse mechanisms including the cell cycle and the PI3K/AKT pathways, among others. All the miRNAs in this figure are upregulated in NKTCL sample, except miRNA-150. This figure adapted from Chen et al. (39) and the appropriate copyright permissions has been obtained from the copyright holder of this work.
Figure 2
Figure 2
The association between EBV-miRNAs and targets in NKTCL. This figure adapted from Huang and Lin (65) and the appropriate copyright permission has been obtained.
See this image and copyright information in PMC

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