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Review
. 2019 Jul 1;8(1):21.
doi: 10.1186/s40169-019-0237-6.

The role of liver microenvironment in hepatic metastasis

Tovah Williamson  1 , Nikhila Sultanpuram  1 , Hossein Sendi  2   3
Affiliations
Review

The role of liver microenvironment in hepatic metastasis

Tovah Williamson et al. Clin Transl Med. .

Abstract

Metastasis is still poorly understood and thus further research must be conducted to provide insight into the driving factors. Novel research has revealed the significance of the microenvironment in the delegation of metastasis, expanding the field of cancer metastasis to cells and cell environments surrounding the migrated tumor cells. Research on hepatic metastasis is an ever-growing domain of this field, as several primary tumors can metastasize to the liver. The two features within the liver that promote metastasis-cellular and acellular-are found in the current interpretation of liver microenvironment. Novel findings of both are included in this review. Different hypotheses detailing the methods by which metastasis can occur must be included to understand the significance of the microenvironment, as well as a brief overview of the methods that can be used during research. This review aims to highlight the importance of liver microenvironment on the development or potential regression of hepatic metastasis through discussing both acellular and cellular components of liver microenvironment and their interaction with metastasis.

Keywords: CTC; Cancer; ECM; Metastatic; Tumor.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Cellular factors playing role in formation and development of metastatic niche within liver microenvironment. This figure depicts the schematic representation of the major cellular components involved in a multistep process in the formation and development of the metastatic niches in the liver microenvironment. (TEM transendothelial migration, MMP metalloproteinases, CCL5 chemokine ligand 5)
See this image and copyright information in PMC

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