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. 1988 Mar;38(3):481-3.
doi: 10.1212/wnl.38.3.481.

Protein redistribution diet restores motor function in patients with dopa-resistant "off" periods

J H Pincus  1 , K Barry
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Protein redistribution diet restores motor function in patients with dopa-resistant "off" periods

J H Pincus et al. Neurology. 1988 Mar.

Abstract

Sixteen parkinsonians with acquired drug-resistant "off" periods without dyskinesia were placed on a diet in which virtually all protein was concentrated in the evening meal. Restoration of sensitivity to levodopa resulted in 88%. Ten patients (62%) have continued to comply with the diet for 7 months (mean). Two patients were studied in detail. Immobility correlated with elevated plasma levels of large neutral amino acids (LNAA), normality with low LNAA.

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