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Review
. 2019 Nov;21(11):e13079.
doi: 10.1111/cmi.13079. Epub 2019 Jul 22.

Canonical and noncanonical inflammasomes in intestinal epithelial cells

Nathaniel Winsor  1 , Christian Krustev  2 , Jessica Bruce  1   3 , Dana J Philpott  1 , Stephen E Girardin  1   2
Affiliations
Review

Canonical and noncanonical inflammasomes in intestinal epithelial cells

Nathaniel Winsor et al. Cell Microbiol. 2019 Nov.

Abstract

Inflammasomes are cytosolic, multimeric protein complexes capable of activating pro-inflammatory cytokines such as IL-1β and IL-18, which play a key role in host defence. Inflammasome components are highly expressed in the intestinal epithelium. In recent years, studies have begun to demonstrate that epithelial-intrinsic inflammasomes play a critical role in regulating epithelial homeostasis, both by defending the epithelium from pathogenic insult and through the regulation of the mucosal environment. However, the majority of research regarding inflammasome activation has focused on professional immune cells, such as macrophages. Here, we present an overview of the current understanding of inflammasome function in epithelial cells and at mucosal surfaces and, in particular, in the intestine.

Keywords: immunology; infection; inflammasome; intestinal epithelium; microbial-cell interaction.

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References

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