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Comment
. 2019 Jul 1;50(1):1-2.
doi: 10.1016/j.devcel.2019.06.005.

A Tense Situation: Maintaining ER Homeostasis during Lipid Droplet Budding

Siti Nur Sarah Morris  1 , James A Olzmann  2
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A Tense Situation: Maintaining ER Homeostasis during Lipid Droplet Budding

Siti Nur Sarah Morris et al. Dev Cell. .
Free article

Abstract

In this issue of Developmental Cell, Chorlay et al. (2019) provide evidence that asymmetric membrane surface tension determines the directionality of lipid droplet (LD) emergence. Furthermore, phospholipid synthesis "refills" the outer leaflet of the endoplasmic reticulum (ER) membrane to maintain cytosolic LD emergence and prevent disruptions to ER homeostasis.

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