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. 2019 Jul 1;55(7):326.
doi: 10.3390/medicina55070326.

Maternal Risk Factors for Stillbirth: A Registry-Based Study

Irisa Zile  1   2 , Inguna Ebela  3 , Ingrida Rumba-Rozenfelde  3
Affiliations

Maternal Risk Factors for Stillbirth: A Registry-Based Study

Irisa Zile et al. Medicina (Kaunas). .

Abstract

Background and Objectives: The number of stillbirths has reduced more slowly than has maternal mortality or mortality in children younger than 5 years, which were explicitly targeted in the Millennium Development Goals. Placental pathologies and infection associated with preterm birth are linked to a substantial proportion of stillbirths. Appropriate preconception care and quality antenatal care that is accessible to all women has the potential to reduce stillbirth rates. The aim of the present study was to assess potential risk factors associated with stillbirth within maternal medical diseases and obstetric complications. Materials and Methods: Retrospective cohort study (2001-2014) was used to analyse data from the Medical Birth Register on stillbirth and live births as controls. Adjusted Odds ratios (aOR) with 95% confidence intervals (CI) were estimated. Multiple regression model adjusted for maternal age, parity and gestational age. Results: The stillbirth rate was 6.2 per 1000 live and stillbirths. The presence of maternal medical diseases greatly increased the risk of stillbirth including diabetes mellitus (aOR = 2.5; p < 0.001), chronic hypertension 3.1 (aOR = 3.1; p < 0.001) and oligohydromnios/polyhydromnios (aOR = 2.4; p < 0.001). Pregnancy complications such as intrauterine growth restriction (aOR = 2.2; p < 0.001) was important risk factor for stillbirth. Abruption was associated with a 2.8 odds of stillbirth. Conclusions: Risk factors most significantly associated with stillbirth include maternal history of chronic hypertension and abruptio placenta which is a common cause of death in stillbirth. Early identification of potential risk factors and appropriate perinatal management are important issues in the prevention of adverse fetal outcomes and preventive strategies need to focus on improving antenatal detection of fetal growth restriction.

Keywords: maternal diseases; risk factors; stillbirth.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Maternal diseases and pregnancy complications associated with stillbirth (aOR; adjusted for maternal age, parity and gestational age and obtained from a logistic regression model).
See this image and copyright information in PMC

References

    1. Lawn J.E., Blencowe H., Pattinson R., Cousens S., Kumar R., Ibiebele I., Gardosi J., Day L.T., Stanton C., Lancet’s Stillbirths Series steering committee Lancet’s Stillbirths Series steering committee. Stillbirths: Where? When? Why? How to make the data count? Lancet. 2011;337:1448–1463. doi: 10.1016/S0140-6736(10)62187-3. - DOI - PubMed
    1. Lawn J.E., Blencowe H., Waiswa P., Amouzou A., Mathers C., Hogan D., Flenady V., Frøen J.F., Qureshi Z.U., Calderwood C., et al. Stillbirths: Rates, risk factors, and acceleration towards 2030. Lancet. 2016;6:587–603. doi: 10.1016/S0140-6736(15)00837-5. - DOI - PubMed
    1. Smith L.K., Hindori-Mohangoo A.D., Delnord M., Durox M., Zeitlin J., Haidinger G., Alexander S., Kolarova R., Rodin U., Kyprianou T., et al. Quantifying the burden of stillbirths before 28 weeks of completed gestational age in high-income countries: a population-based study of 19 European countries. Lancet. 2018;392:1639–1646. doi: 10.1016/S0140-6736(18)31651-9. - DOI - PubMed
    1. Frøen J.F., Gordijn S.J., Abdel-Aleem H., Bergsjø P., Betran A., Duke C.W., Fauveau V., Flenady V., Hinderaker S.G., Hofmeyr G.J., et al. Making stillbirths count, making numbers talk—Issues in data collection for stillbirths. BMC Pregnancy Childbirth. 2009;9:58. doi: 10.1186/1471-2393-9-58. - DOI - PMC - PubMed
    1. Cuttini M., Gissler M., Loghi M., Heino A., Bruin K.V.D.P.-D., Zeitlin J., Hindori-Mohangoo A., Prunet C., Blondel B., Smith L., et al. How do late terminations of pregnancy affect comparisons of stillbirth rates in Europe? Analyses of aggregated routine data from the Euro-Peristat Project. BJOG: Int. J. Obstet. Gynaecol. 2017;125:226–234. - PubMed