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. 2019 Jun 25;99(24):1870-1874.
doi: 10.3760/cma.j.issn.0376-2491.2019.24.007.

[Association between interleukin-17A and 17F single nucleotide polymorphisms and knee osteoarthritis]

[Article in Chinese]
P L Zhang  1 , F M Yang  1 , Z Z Qiao  2 , J Liu  1 , Q Y Yang  1 , Y J Wang  1 , M Qi  1 , L N Cui  1 , L Meng  3 , X P Li  1
Affiliations

[Association between interleukin-17A and 17F single nucleotide polymorphisms and knee osteoarthritis]

[Article in Chinese]
P L Zhang et al. Zhonghua Yi Xue Za Zhi. .

Abstract
in English, Chinese

Objective: To investigate the association between single nucleotide polymorphisms (SNP) of IL-17A (rs2275913) and IL-17F (rs763780) genes and susceptibility to knee osteoarthritis (KOA) in Chinese Han and Tibetan populations. Methods: A case-control study was conducted. Total of 122 Han KOA patients and 124 Han healthy controls and 76 Tibetan KOA patients and 68 Tibetan healthy controls in Qinghai Province were selected between 2015 and 2017. SNP typing was performed on four groups of rs2275913 and rs763780 polymorphisms by polymerease chain reaction (PCR)-sequencing to detect IL-17A and IL-17 F genotype frequencies and allele frequencies. The t test was used to compare data between groups. Results: The genotype AA frequency of IL-17A (rs2275913) was significantly different between the Han KOA and the control group (OR=2.625, P=0.016). Compared with the frequency of allele A in healthy control group, the allele A frequency in Han KOA group was significantly higher(OR=1.445, P=0.047); the genotype frequency of IL-17A,however,was comparable between the KOA and the healthy control in Tibetan population (OR=1.696, 1.355, both P>0.05); there were also not difference in the IL-17F (rs763780) genotype frequency and allele frequency between the Han KOA and Tibetan KOA groups and two control groups,respectively (OR=1.346, 1.126, both P>0.05). Conclusion: It is highly likely that the pathogenesis of KOA in Chinese Han population is positively related to the genotype AA and allele A of IL-17A (rs2275913).

目的： 探讨白细胞介素（IL）-17A（rs2275913）和IL-17F（rs763780）基因单核苷酸多态性与中国汉族及藏族人群膝骨关节炎（KOA）易感性的相关性。 方法： 采用病例对照研究，于2015至2017年选取青海地区汉族KOA患者122例、汉族健康对照124名及藏族KOA患者76例、藏族健康对照68名。采用聚合酶链反应（PCR）测序法对rs2275913及rs763780多态性位点在4组样本中进行单核苷酸多态性（SNP）分型，检测IL-17A和IL-17 F基因型频率及等位基因频率。两组计量资料比较采用t检验。 结果： IL-17A（rs2275913）的基因型AA频率在汉族KOA组和对照组之间有显著性差异（OR=2.625，P=0.016）；汉族KOA组与对照组等位基因A频率差异有统计学意义（OR=1.445，P=0.047）；藏族KOA组及对照组IL-17A的基因型频率差异无统计学意义（OR=1.696、1.355，均P>0.05）；IL-17F（rs763780）基因型频率及等位基因频率在汉族、藏族KOA组及对照组之间差异均无统计学意义（OR=1.346、1.126，均P>0.05）。 结论： IL-17A（rs2275913）的基因型AA和等位基因A可能与汉族KOA的发病相关。.

Keywords: Allele; Genotype; Knee osteoarthritis; Single nucleotide polymorphism; Susceptibility.

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