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. 2019 Jul 1;57(7):508-512.
doi: 10.3760/cma.j.issn.0529-5815.2019.07.006.

[Paying attention to the diagnosis and treatment of IgG4-related sclerosing cholangitis]

[Article in Chinese]
B L Li  1 , J C Xiao
Affiliations

[Paying attention to the diagnosis and treatment of IgG4-related sclerosing cholangitis]

[Article in Chinese]
B L Li et al. Zhonghua Wai Ke Za Zhi. .

Abstract
in English, Chinese

IgG4-related sclerosing cholangitis (IgG4-SC) is characterized by biliary strictures and obstructive jaundice.Elevated levels of serum IgG4 and a multifocal IgG4-rich lymphoplasmacytic infiltration of affected organs are also the characteristics of IgG4-SC. Prednisone is recommended in the initial treatment of IgG4-SC. The differential diagnosis between IgG4-SC and cholangiocarcinoma is not easy. Comprehensively collection of medical history, paying attention to other organs involvement, and getting the pathologic diagnosis are important for diagnosis of this disease. In order to prevent misdiagnosis we should learn more about IgG4-SC. On the other hand, if we can not differentiate IgG4-SC and cholangiocarcinoma, operation may be recommended.

IgG4相关性胆管炎（IgG4-SC）多以梗阻性黄疸为主要临床表现，以血清学IgG4升高为特点，以胆管壁密集的IgG4阳性浆细胞浸润为病理特征，以类固醇类激素为首选治疗方案。IgG4-SC与胆管癌的鉴别诊断较为困难，应全面收集病史，关注其他器官受累情况，争取获得病理诊断。对于IgG4-SC，我们既要重视，避免漏诊；同时也应慎重，避免误诊。如果术前不能除外胆道肿瘤，应进行必要的手术探查。.

Keywords: Cholangitis; Diagnosis; Treatment.

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