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Randomized Controlled Trial
. 2019 Aug 8;49(4):1008-1013.
doi: 10.3906/sag-1812-133.

Mesh nebulizer is as effective as jet nebulizer in clinical practice of acute asthma in children

Özge Soyer  1 , Melike Kahveci  1 , Betül Büyüktiryaki  1 , Ebru Arık Yılmaz  1 , Betül Karaatmaca  1 , Saliha Esenboğa  1 , Pınar Gür Çetinkaya  1 , Ümit Murat Şahiner  1 , Bülent Enis Şekerel  1
Affiliations
Randomized Controlled Trial

Mesh nebulizer is as effective as jet nebulizer in clinical practice of acute asthma in children

Özge Soyer et al. Turk J Med Sci. .

Abstract

Background/aim: The aim of this study was to compare the effect of salbutamol delivered to children by jet nebulizer (JN) and mesh nebulizer (MN).

Materials and methods: Children admitted with acute asthma were treated with 3 doses of nebulized salbutamol, 1 given by MN. The patients’ vital signs, lung function measurements, modified pulmonary index score (MPIS), and whole body plethysmography (WBP) measurements were evaluated before and 20 min after each dose of salbutamol.

Results: Thirty-onechildren [9.5 (6.4–17.2) years, 67.7% male, 32.3% female] with mild (67.7%) and moderate (32.3%) asthma attacks were included in the study. The improvements with MN were comparable with JN in terms of changes in pretreatment and posttreatment forced expiratory volume in the first second (FEV1) (2.57 ± 4.57, 3.65 ± 5.44; P = 0.44), forced vital capacity (FVC) (2.52 ± 5.29, 4.17 ± 7.54; P = 0.28), heart rate (7.33 ± 10.21, 4.14 ± 9.32; P = 0.24), peripheral capillary oxygen saturation (SpO2) (0.38 ± 0.23, 0.43 ± 0.15; P = 0.83), and modified pulmonary index score (MPIS) (−6.30 ± 22.70, −8.77 ± 25.46; P = 0.70). The pre- and posttreatment values of total lung capacity (TLC), residual volume (RV), specific conductance (sGaw), and RV/TLC were similar for the JN and MN groups. Adverse effects were not different: however, complaints of palpitation were significantly higher in the posttreatment MN group than the pretreatment MN group (32.3% vs 9.7%, respectively, P = 0.016).

Conclusion: These findings support the previous evidence found in studies of adults that MN is as effective as and as safe as JN in the treatment of acute asthma in children

Keywords: Asthma; children; jet nebulizer; mesh nebulizer; spirometry; whole body plethysmography.

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Conflict of interest statement

CONFLICT OF INTEREST:

none declared

Figures

Figure
Figure
Scheme of the study.
See this image and copyright information in PMC

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