Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988;306(1):1-4.

[Absence of a close linkage between Alzheimer's disease and the polymorphic probe coding for superoxide dismutase 1]

[Article in French]
F David  1 , S Intrator, J F Foncin, D Salmon, G Lucotte
Affiliations
  • PMID: 3126980

[Absence of a close linkage between Alzheimer's disease and the polymorphic probe coding for superoxide dismutase 1]

[Article in French]
F David et al. C R Acad Sci III. 1988.

Abstract

The hypothesis of a tight linkage between Alzheimer's disease (AD), a presenile dementia, and the probe coding for superoxide dismutase 1 (SOD 1), located on chromosome 21 at 21q22, has been investigated in a large family originating from Calabria, in which AD is transmitted as an autosomal dominant mendelian trait. Analysis of the Msp I restriction polymorphism, after molecular hybridization with the probe of DNAs coming from 22 subjects of the pedigree, allowed to the demonstrate that there wasn't any tight linkage between AD and the marker studied.

PubMed Disclaimer

Publication types

Substances