On the issue of transparency and reproducibility in nanomedicine

Hon S Leong^{1

2}, Kimberly S Butler³, C Jeffrey Brinker^{4

5

6

7}, May Azzawi^{8

9}, Steve Conlan^{9

10}, Christine Dufés^{9

11}, Andrew Owen^{9

12}, Steve Rannard^{9

13}, Chris Scott^{9

14}, Chunying Chen¹⁵, Marina A Dobrovolskaia^{16

17}, Serguei V Kozlov¹⁷, Adriele Prina-Mello^{18

19

20}, Ruth Schmid²¹, Peter Wick²², Fanny Caputo²³, Patrick Boisseau²³, Rachael M Crist¹⁶, Scott E McNeil¹⁶, Bengt Fadeel²⁴, Lang Tran²⁵, Steffen Foss Hansen²⁶, Nanna B Hartmann²⁶, Lauge P W Clausen²⁶, Lars M Skjolding²⁶, Anders Baun²⁶, Marlene Ågerstrand²⁷, Zhen Gu²⁸, Dimitrios A Lamprou²⁹, Clare Hoskins³⁰, Leaf Huang³¹, Wantong Song³², Huiliang Cao^{33

34}, Xuanyong Liu³³, Klaus D Jandt³⁴, Wen Jiang³⁵, Betty Y S Kim³⁶, Korin E Wheeler³⁷, Andrew J Chetwynd³⁸, Iseult Lynch³⁸, Seyed Moein Moghimi^{39

40}, André Nel⁴¹, Tian Xia⁴¹, Paul S Weiss^{42

43

44}, Bruno Sarmento^{45

46}, José das Neves^{45

46}, Hélder A Santos⁴⁷, Luis Santos⁴⁸, Samir Mitragotri⁴⁹, Steve Little⁵⁰, Dan Peer⁵¹, Mansoor M Amiji⁵², Maria José Alonso⁵³, Alke Petri-Fink⁵⁴, Sandor Balog⁵⁴, Aaron Lee⁵⁴, Barbara Drasler⁵⁴, Barbara Rothen-Rutishauser⁵⁵, Stefan Wilhelm^{56

57}, Handan Acar^{56

57}, Roger G Harrison^{56

57

58}, Chuanbin Mao^{57

59

60}, Priyabrata Mukherjee^{57

61}, Rajagopal Ramesh^{57

61}, Lacey R McNally^{62

63}, Sara Busatto^{64

65

66

67}, Joy Wolfram^{64

65

68}, Paolo Bergese^{66

67}, Mauro Ferrari^{68

69}, Ronnie H Fang⁷⁰, Liangfang Zhang⁷¹, Jie Zheng⁷², Chuanqi Peng⁷², Bujie Du⁷², Mengxiao Yu⁷², Danielle M Charron⁷³, Gang Zheng⁷⁴, Chiara Pastore⁷⁵

Affiliations

¹ Department of Urology, Mayo Clinic, Rochester, MN, USA.
² Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
³ Department of Nanobiology, Sandia National Laboratories, Albuquerque, NM, USA.
⁴ Center for Micro-Engineered Materials, University of New Mexico Albuquerque, Albuquerque, NM, USA.
⁵ Departments of Chemical and Biological Engineering, University of New Mexico, Albuquerque, NM, USA.
⁶ Department of Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, NM, USA.
⁷ UNM Comprehensive Cancer Center, University of New Mexico, Albuquerque, NM, USA.
⁸ Cardiovascular Research Group, School of Healthcare Science, Manchester Metropolitan University, Manchester, UK.
⁹ British Society for Nanomedicine.
¹⁰ Institute of Life Science, Swansea University Medical School, Swansea University, Swansea, UK.
¹¹ Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.
¹² Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
¹³ Department of Chemistry, School of Physical Sciences, University of Liverpool, Liverpool, UK.
¹⁴ Centre for Cancer Research and Cell Biology, Queen's University of Belfast, Belfast, UK.
¹⁵ National Center for Nanoscience and Technology of China, Beijing, China.
¹⁶ Cancer Research Technology Program, Nanotechnology Characterization Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
¹⁷ Laboratory of Animal Sciences Program, Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
¹⁸ Trinity Translational Medicine Institute, Department of Clinical Medicine, Trinity College Dublin, Dublin, Ireland.
¹⁹ Laboratory for Biological Characterisation of Advanced Materials, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
²⁰ Nanomedicine Group, Advanced Materials and Bioengineering Research (AMBER) centre, Centre for Research on Adaptive Nanostructures and Nanodevices, Trinity College Dublin, Dublin, Ireland.
²¹ SINTEF Industry, Trondheim, Norway.
²² Empa - Swiss Federal Laboratories for Materials Science and Technology, St Gallen, Switzerland.
²³ University Grenoble Alpes, CEA, LETI, Grenoble, Switzerland.
²⁴ Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
²⁵ Institute of Occupational Medicine, Edinburgh, UK.
²⁶ Department of Environmental Engineering, Technical University of Denmark, Kongens Lyngby, Denmark.
²⁷ Department of Environmental Science and Analytical Chemistry (ACES), Stockholm University, Stockholm, Sweden.
²⁸ Department of Bioengineering, California Nanosystems Institute, University of California, Los Angeles, Los Angeles, CA, USA.
²⁹ School of Pharmacy, Queen's University Belfast, Belfast, UK.
³⁰ Institute of Science and Technology in Medicine, Keele University, Keele, UK.
³¹ Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.
³² Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China.
³³ State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, China.
³⁴ Otto Schott Institute of Materials Research, Friedrich Schiller University Jena, Jena, Germany.
³⁵ Department of Radiation Oncology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
³⁶ Department of Neurosurgery, The University of Texas MD Anderson Cancer, Houston, TX, USA.
³⁷ Department of Chemistry and Biochemistry, Santa Clara University, Santa Clara, CA, USA.
³⁸ School of Geography Earth and Environmental Sciences, University of Birmingham, Birmingham, UK.
³⁹ School of Pharmacy, Newcastle University, Newcastle upon Tyne, UK.
⁴⁰ Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
⁴¹ Division of NanoMedicine, Department of Medicine, California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, USA.
⁴² Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.
⁴³ Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.
⁴⁴ Department of Materials Science and Engineering, California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, USA.
⁴⁵ i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
⁴⁶ INEB - Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal.
⁴⁷ Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.
⁴⁸ Dosage Form Design and Development, MedImmune, LLC, Gaithersburg, MD, USA.
⁴⁹ Wyss Institute of Biologically Inspired Engineering, Harvard University, Cambridge, MA, USA.
⁵⁰ Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
⁵¹ George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.
⁵² School of Pharmacy, Northeastern University, Boston, MA, USA.
⁵³ CIMUS Research Institute, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
⁵⁴ Adolphe Merkle Institute, University of Fribourg, Fribourg, Switzerland.
⁵⁵ Department of Chemistry, University of Fribourg, Fribourg, Switzerland.
⁵⁶ Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, USA.
⁵⁷ Stephenson Cancer Center, Oklahoma City, OK, USA.
⁵⁸ School of Chemical, Biological and Materials Engineering, University of Oklahoma, Norman, OK, USA.
⁵⁹ Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK, USA.
⁶⁰ School of Materials Science and Engineering, Zhejiang University, Hangzhou, Zhejiang, China.
⁶¹ Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
⁶² Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
⁶³ Department of Bioengineering, Wake Forest School of Medicine, Winston-Salem, NC, USA.
⁶⁴ Department of Transplantation Medicine, Mayo Clinic, Jacksonville, FL, USA.
⁶⁵ Department of Physiology and Biomedical Engineering, Mayo Clinic, Jacksonville, FL, USA.
⁶⁶ Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
⁶⁷ CSGI, Research Center for Colloids and Nanoscience, Florence, Italy.
⁶⁸ Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, USA.
⁶⁹ Department of Medicine, Weill Cornell Medicine, Weill Cornell Medicine, New York, NY, USA.
⁷⁰ Department of NanoEngineering, Chemical Engineering Program, University of California, San Diego, La Jolla, CA, USA.
⁷¹ Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA.
⁷² Department of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX, USA.
⁷³ Institute of Biomaterials and Biomedical Engineering, University of Toronto Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
⁷⁴ Department of Medical Biophysics, University of Toronto Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
⁷⁵ Nature Nanotechnology, London, UK. Chiara.Pastore@nature.com.

PMID: 31270452
PMCID: PMC6939883
DOI: 10.1038/s41565-019-0496-9

On the issue of transparency and reproducibility in nanomedicine

Hon S Leong et al. Nat Nanotechnol. 2019 Jul.

. 2019 Jul;14(7):629-635.

doi: 10.1038/s41565-019-0496-9.

Authors

Affiliations

¹ Department of Urology, Mayo Clinic, Rochester, MN, USA.
² Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
³ Department of Nanobiology, Sandia National Laboratories, Albuquerque, NM, USA.
⁴ Center for Micro-Engineered Materials, University of New Mexico Albuquerque, Albuquerque, NM, USA.
⁵ Departments of Chemical and Biological Engineering, University of New Mexico, Albuquerque, NM, USA.
⁶ Department of Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, NM, USA.
⁷ UNM Comprehensive Cancer Center, University of New Mexico, Albuquerque, NM, USA.
⁸ Cardiovascular Research Group, School of Healthcare Science, Manchester Metropolitan University, Manchester, UK.
⁹ British Society for Nanomedicine.
¹⁰ Institute of Life Science, Swansea University Medical School, Swansea University, Swansea, UK.
¹¹ Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.
¹² Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
¹³ Department of Chemistry, School of Physical Sciences, University of Liverpool, Liverpool, UK.
¹⁴ Centre for Cancer Research and Cell Biology, Queen's University of Belfast, Belfast, UK.
¹⁵ National Center for Nanoscience and Technology of China, Beijing, China.
¹⁶ Cancer Research Technology Program, Nanotechnology Characterization Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
¹⁷ Laboratory of Animal Sciences Program, Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
¹⁸ Trinity Translational Medicine Institute, Department of Clinical Medicine, Trinity College Dublin, Dublin, Ireland.
¹⁹ Laboratory for Biological Characterisation of Advanced Materials, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
²⁰ Nanomedicine Group, Advanced Materials and Bioengineering Research (AMBER) centre, Centre for Research on Adaptive Nanostructures and Nanodevices, Trinity College Dublin, Dublin, Ireland.
²¹ SINTEF Industry, Trondheim, Norway.
²² Empa - Swiss Federal Laboratories for Materials Science and Technology, St Gallen, Switzerland.
²³ University Grenoble Alpes, CEA, LETI, Grenoble, Switzerland.
²⁴ Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
²⁵ Institute of Occupational Medicine, Edinburgh, UK.
²⁶ Department of Environmental Engineering, Technical University of Denmark, Kongens Lyngby, Denmark.
²⁷ Department of Environmental Science and Analytical Chemistry (ACES), Stockholm University, Stockholm, Sweden.
²⁸ Department of Bioengineering, California Nanosystems Institute, University of California, Los Angeles, Los Angeles, CA, USA.
²⁹ School of Pharmacy, Queen's University Belfast, Belfast, UK.
³⁰ Institute of Science and Technology in Medicine, Keele University, Keele, UK.
³¹ Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.
³² Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China.
³³ State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, China.
³⁴ Otto Schott Institute of Materials Research, Friedrich Schiller University Jena, Jena, Germany.
³⁵ Department of Radiation Oncology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
³⁶ Department of Neurosurgery, The University of Texas MD Anderson Cancer, Houston, TX, USA.
³⁷ Department of Chemistry and Biochemistry, Santa Clara University, Santa Clara, CA, USA.
³⁸ School of Geography Earth and Environmental Sciences, University of Birmingham, Birmingham, UK.
³⁹ School of Pharmacy, Newcastle University, Newcastle upon Tyne, UK.
⁴⁰ Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
⁴¹ Division of NanoMedicine, Department of Medicine, California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, USA.
⁴² Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.
⁴³ Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.
⁴⁴ Department of Materials Science and Engineering, California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, USA.
⁴⁵ i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
⁴⁶ INEB - Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal.
⁴⁷ Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.
⁴⁸ Dosage Form Design and Development, MedImmune, LLC, Gaithersburg, MD, USA.
⁴⁹ Wyss Institute of Biologically Inspired Engineering, Harvard University, Cambridge, MA, USA.
⁵⁰ Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
⁵¹ George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.
⁵² School of Pharmacy, Northeastern University, Boston, MA, USA.
⁵³ CIMUS Research Institute, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
⁵⁴ Adolphe Merkle Institute, University of Fribourg, Fribourg, Switzerland.
⁵⁵ Department of Chemistry, University of Fribourg, Fribourg, Switzerland.
⁵⁶ Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, USA.
⁵⁷ Stephenson Cancer Center, Oklahoma City, OK, USA.
⁵⁸ School of Chemical, Biological and Materials Engineering, University of Oklahoma, Norman, OK, USA.
⁵⁹ Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK, USA.
⁶⁰ School of Materials Science and Engineering, Zhejiang University, Hangzhou, Zhejiang, China.
⁶¹ Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
⁶² Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
⁶³ Department of Bioengineering, Wake Forest School of Medicine, Winston-Salem, NC, USA.
⁶⁴ Department of Transplantation Medicine, Mayo Clinic, Jacksonville, FL, USA.
⁶⁵ Department of Physiology and Biomedical Engineering, Mayo Clinic, Jacksonville, FL, USA.
⁶⁶ Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
⁶⁷ CSGI, Research Center for Colloids and Nanoscience, Florence, Italy.
⁶⁸ Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, USA.
⁶⁹ Department of Medicine, Weill Cornell Medicine, Weill Cornell Medicine, New York, NY, USA.
⁷⁰ Department of NanoEngineering, Chemical Engineering Program, University of California, San Diego, La Jolla, CA, USA.
⁷¹ Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA.
⁷² Department of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX, USA.
⁷³ Institute of Biomaterials and Biomedical Engineering, University of Toronto Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
⁷⁴ Department of Medical Biophysics, University of Toronto Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
⁷⁵ Nature Nanotechnology, London, UK. Chiara.Pastore@nature.com.

PMID: 31270452
PMCID: PMC6939883
DOI: 10.1038/s41565-019-0496-9

Erratum in

Publisher Correction: On the issue of transparency and reproducibility in nanomedicine.
Leong HS, Butler KS, Brinker CJ, Azzawi M, Conlan S, Dufès C, Owen A, Rannard S, Scott C, Chen C, Dobrovolskaia MA, Kozlov SV, Prina-Mello A, Schmid R, Wick P, Caputo F, Boisseau P, Crist RM, McNeil SE, Fadeel B, Tran L, Hansen SF, Hartmann NB, Clausen LPW, Skjolding LM, Baun A, Ågerstrand M, Gu Z, Lamprou DA, Hoskins C, Huang L, Song W, Cao H, Liu X, Jandt KD, Jiang W, Kim BYS, Wheeler KE, Chetwynd AJ, Lynch I, Moghimi SM, Nel A, Xia T, Weiss PS, Sarmento B, Neves JD, Santos HA, Santos L, Mitragotri S, Little S, Peer D, Amiji MM, Alonso MJ, Petri-Fink A, Balog S, Lee A, Drasler B, Rothen-Rutishauser B, Wilhelm S, Acar H, Harrison RG, Mao C, Mukherjee P, Ramesh R, McNally LR, Busatto S, Wolfram J, Bergese P, Ferrari M, Fang RH, Zhang L, Zheng J, Peng C, Du B, Yu M, Charron DM, Zheng G, Pastore C. Leong HS, et al. Nat Nanotechnol. 2019 Aug;14(8):811. doi: 10.1038/s41565-019-0523-x. Nat Nanotechnol. 2019. PMID: 31289407
Publisher Correction: On the issue of transparency and reproducibility in nanomedicine.
Leong HS, Butler KS, Brinker CJ, Azzawi M, Conlan S, Dufès C, Owen A, Rannard S, Scott C, Chen C, Dobrovolskaia MA, Kozlov SV, Prina-Mello A, Schmid R, Wick P, Caputo F, Boisseau P, Crist RM, McNeil SE, Fadeel B, Tran L, Hansen SF, Hartmann NB, Clausen LPW, Skjolding LM, Baun A, Ågerstrand M, Gu Z, Lamprou DA, Hoskins C, Huang L, Song W, Cao H, Liu X, Jandt KD, Jiang W, Kim BYS, Wheeler KE, Chetwynd AJ, Lynch I, Moghimi SM, Nel A, Xia T, Weiss PS, Sarmento B, das Neves J, Santos HA, Santos L, Mitragotri S, Little S, Peer D, Amiji MM, Alonso MJ, Petri-Fink A, Balog S, Lee A, Drasler B, Rothen-Rutishauser B, Wilhelm S, Acar H, Harrison RG, Mao C, Mukherjee P, Ramesh R, McNally LR, Busatto S, Wolfram J, Bergese P, Ferrari M, Fang RH, Zhang L, Zheng J, Peng C, Du B, Yu M, Charron DM, Zheng G, Pastore C. Leong HS, et al. Nat Nanotechnol. 2019 Sep;14(9):902. doi: 10.1038/s41565-019-0538-3. Nat Nanotechnol. 2019. PMID: 31358944 Free PMC article.

No abstract available

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Comment in

A few clarifications on MIRIBEL.
Faria M, Björnmalm M, Crampin EJ, Caruso F. Faria M, et al. Nat Nanotechnol. 2020 Jan;15(1):2-3. doi: 10.1038/s41565-019-0612-x. Nat Nanotechnol. 2020. PMID: 31925392 No abstract available.

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On the issue of transparency and reproducibility in nanomedicine

Affiliations

On the issue of transparency and reproducibility in nanomedicine

Authors

Affiliations

Erratum in

Comment in

References

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MeSH terms

Grants and funding

LinkOut - more resources

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