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. 2019 Sep;593(18):2655-2664.
doi: 10.1002/1873-3468.13527. Epub 2019 Jul 17.

Compositional and functional features of the female premenopausal and postmenopausal gut microbiota

Hui Zhao  1   2 , Juanjuan Chen  2   3 , Xiaoping Li  2 , Qiang Sun  4 , Panpan Qin  1   2 , Qi Wang  1   2
Affiliations
Free article

Compositional and functional features of the female premenopausal and postmenopausal gut microbiota

Hui Zhao et al. FEBS Lett. 2019 Sep.
Free article

Abstract

Endogenous estrogen deficiency accelerates many diseases in postmenopausal women, and gut microbes contribute to estrogen level modulation. However, the compositional alterations and influences of the gut microbiota in postmenopausal women remain uncertain. A metagenome-wide association study was performed to compare the gut microbiota of 24 premenopausal and 24 postmenopausal women. Firmicutes and Roseburia spp. are depleted, while Bacteroidetes and the toluene-producing genus Tolumonas are overrepresented in fecal samples from postmenopausal women. The pentose phosphate pathway is enriched in premenopausal women. Homocysteine synthesis-related processes are enriched in postmenopausal women. The gut microbiomes of premenopausal and postmenopausal women differ and produce different metabolites. The gut microbiome may be a therapeutic target to reduce risks and improve the quality of life in postmenopausal women.

Keywords: antioxidant capacity; gut metabolic modules; gut microbiome diversity; postmenopausal diseases; shotgun metagenomic sequencing.

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References

    1. Atsma F, Bartelink M-LEL, Grobbee DE and van der Schouw YT (2006) Postmenopausal status and early menopause as independent risk factors for cardiovascular disease: a meta-analysis. Menopause 13, 265-279.
    1. Pu D, Tan R, Yu Q and Wu J (2017) Metabolic syndrome in menopause and associated factors: a meta-analysis. Climacteric 20, 583-591.
    1. Sampson JN, Falk RT, Schairer C, Moore SC, Fuhrman BJ, Dallal CM, Bauer DC, Dorgan JF, Shu X-O, Zheng W et al. (2017) Association of Estrogen metabolism with breast cancer risk in different cohorts of postmenopausal women. Cancer Res 77, 918-925.
    1. Madak-Erdogan Z, Band S, Zhao YC, Smith BP, Kulkoyluoglu-Cotul E, Zuo Q, Santaliz Casiano A, Wrobel K, Rossi G, Smith RL et al. (2019) Free fatty acids rewire cancer metabolism in obesity-associated breast cancer via estrogen receptor and mTOR signaling. Cancer Res. 79, 2494-2510.
    1. Lizcano F and Guzman G (2014) Estrogen deficiency and the origin of obesity during menopause. Biomed Res Int 2014, 757461.

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