Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Jan;97(1):15-23.
doi: 10.1002/cyto.a.23851. Epub 2019 Jul 5.

Advances of In Vivo Flow Cytometry on Cancer Studies

Yuanzhen Suo  1   2 , Zhenqin Gu  3 , Xunbin Wei  4   5
Affiliations
Review

Advances of In Vivo Flow Cytometry on Cancer Studies

Yuanzhen Suo et al. Cytometry A. 2020 Jan.

Abstract

Cancer is a big threat to human life. Asia has about 60% of the global population and accounts for half of global cancer incidence and mortality. Circulating tumor cells (CTCs) have been a good biomarker for cancer diagnosis, staging, and prognosis. Conventional detection methods of CTCs require drawing blood. It may disturb the biological environment and limited real-time monitoring. in vivo flow cytometry (IVFC) is a burgeoning technique that allows noninvasive detection of CTCs in vivo. Here, we review the technical development of IVFC based on various contrast principles, including fluorescence IVFC, photoacoustic IVFC, imaging IVFC, and label-free IVFC. This powerful tool has been applied widely in many areas of cancer-related studies, especially the CTC studies. We review applications of IVFC in preclinical studies on prevalent cancers in Asia, including liver cancer, blood cancer, and so forth. Other cancer-related studies in breast cancer, prostate cancer, cancer-related stem cell research and drug studies are also reviewed. © 2019 International Society for Advancement of Cytometry.

Keywords: circulating tumor cells; in vivo flow cytometry; prevalent cancers in Asia.

PubMed Disclaimer

References

REFERENCE

    1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018;68:394-424.
    1. Poste G, Fidler IJ. The pathogenesis of cancer metastasis. Nature 1980;283:139-146.
    1. Nguyen DX, Massagué J. Genetic determinants of cancer metastasis. Nat Rev Genet 2007;8:341-352.
    1. Gupta GP, Massagué J. Cancer metastasis: Building a framework. Cell 2006;127:679-695.
    1. Chaffer CL, Weinberg RA. A perspective on cancer cell metastasis. Science 2011;331:1559-1564.

Publication types