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. 2019 Jun 19:12:156.
doi: 10.3389/fnmol.2019.00156. eCollection 2019.

The Emerging Role of microRNAs in Polyglutamine Diseases

Xiaoyu Dong  1 , Shuyan Cong  1
Affiliations

The Emerging Role of microRNAs in Polyglutamine Diseases

Xiaoyu Dong et al. Front Mol Neurosci. .

Abstract

MicroRNAs (miRNAs) are small non-coding molecules that regulate a large amount of post-transcriptional repressor genes by recognizing semi-complementary target sequences that are normally located in the 3' UTR of the mRNA. Altered expression of miRNA has been related to several pathological processes, including polyglutamine (Poly Q) diseases. Specific expression patterns in the circulating fluids and brain parenchyma have been speculated as potential biomarkers for Poly Q disease diagnosis and prognosis. Several miRNAs have been consistently identified in diseases including Huntington's disease (HD) and spinocerebellar ataxia (SCA). In our review, we describe the emerging role of miRNAs in Poly Q diseases and provide an overview on general miRNA biology, implications in pathophysiology, and their potential roles as future biomarkers and applications for therapy.

Keywords: biomarker; microRNAs; neurodegeneration; polyglutamine diseases; therapy.

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References

    1. Bettencourt C., Lima M. (2011). Machado-Joseph Disease: from first descriptions to new perspectives. Orphanet J. Rare Dis. 6:35. 10.1186/1750-1172-6-35 - DOI - PMC - PubMed
    1. Bicker S., Lackinger M., Weiss K., Schratt G. (2014). MicroRNA-132,-134, and -138: a microRNA troika rules in neuronal dendrites. Cell. Mol. Life Sci. 71, 3987–4005. 10.1007/s00018-014-1671-7 - DOI - PMC - PubMed
    1. Borel F., van Logtenstein R., Koornneef A., Maczuga P., Ritsema T., Petry H., et al. . (2011). In vivo knock-down of multidrug resistance transporters ABCC1 and ABCC2 by AAV-delivered shRNAs and by artificial miRNAs. J. RNAi Gene Silencing 7, 434–442. - PMC - PubMed
    1. Borgonio-Cuadra V. M., Valdez-Vargas C., Romero-Córdoba S., Hidalgo-Miranda A., Tapia-Guerrero Y., Cerecedo-Zapata C. M., et al. . (2019). Wide profiling of circulating MicroRNAs in spinocerebellar ataxia type 7. Mol. Neurobiol. [Epub ahead of print]. 10.1007/s12035-019-1480-y - DOI - PubMed
    1. Boudreau R. L., Mcbride J. L., Martins I., Shen S., Xing Y., Carter B. J., et al. . (2009). Nonallele-specific silencing of mutant and wild-type huntingtin demonstrates therapeutic efficacy in Huntington’s disease mice. Mol. Ther. 17, 1053–1063. 10.1038/mt.2009.17 - DOI - PMC - PubMed

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