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. 2019 May 16;18(1):65-72.
doi: 10.1007/s40200-019-00391-5. eCollection 2019 Jun.

Diabetes mellitus and cancer incidence: the Atherosclerosis Risk in Communities (ARIC) cohort study

Hadith Rastad  1 , Mahboubeh Parsaeian  1 , Nooshin Shirzad  2   3 , Mohammad Ali Mansournia  1 , Kamran Yazdani  1
Affiliations

Diabetes mellitus and cancer incidence: the Atherosclerosis Risk in Communities (ARIC) cohort study

Hadith Rastad et al. J Diabetes Metab Disord. .

Abstract

Purpose: To assess the association between diabetes mellitus (DM) and the incidence of cancer at different sites.

Methods: Data from the baseline and first three follow-up visits of the Atherosclerosis Risk in Communities (ARIC) study, an ongoing cohort study of adults from four American communities, were used in this study. Of 15,792 persons aged 45-64 years old who participated in the baseline visit, the data of 15,118 participants were available for this study. For each cancer site, a conditional stratified Poisson regression model was fitted to estimate the adjusted relative rate and 95% confidence interval (adj. RR, 95% CI) of its incidence in diabetics compared to non-diabetics.

Results: We excluded 850 participants with a history of cancer at baseline and 149 participants who developed cancer during 2 years after enrollment, leaving a total of 14,119 participants of whom 1721 were diabetics. Independent of age, body mass index, alcohol consumption, and physical activity, DM decreased the risk of all cancers combined (adj. RR: 0.77, 95% CI: 0.60, 0.98) and the risk of prostate cancer (adj. RR: 0.51, 95% CI: 0.27, 0.97) and increased the risk of colorectal cancer in non-menopausal women (adj. RR: 12.08, 95% CI: 2.06, 70.94).

Conclusions: In conclusion, DM may be associated with an increased risk of colorectal cancer in non-menopausal women and a decreased risk of prostate cancer and all cancers combined.

Keywords: Cancer; Cohort study; Diabetes mellitus; Poisson regression.

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Conflict of interest statement

Competing interestsThe authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Flow-chart of the included participants
See this image and copyright information in PMC

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