Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2019:3:2470547019852073.
doi: 10.1177/2470547019852073. Epub 2019 Jun 16.

"Does the opioid system block or enhance the antidepressant effects of ketamine?"

Sanjay J Mathew  1   2 , Ana Maria Rivas-Grajales  1   2
Affiliations
Comment

"Does the opioid system block or enhance the antidepressant effects of ketamine?"

Sanjay J Mathew et al. Chronic Stress (Thousand Oaks). 2019.
No abstract available

Keywords: antidepressant; depression; ketamine; naltrexone; opioid.

PubMed Disclaimer

Conflict of interest statement

The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Dr Mathew has received consulting fees from Alkermes, Allergan, Bracket, Clexio Biosciences, Janssen, Perception Neurosciences, and Sage Therapeutics. He has received research support from Biohaven Pharmaceuticals and VistaGen Therapeutics.

Comment on

References

    1. Zanos P, Gould TD. Mechanisms of ketamine action as an antidepressant. Mol Psychiatry. 2018; 23(4): 801–811. - PMC - PubMed
    1. Moda-Sava RN, Murdock MH, Parekh PK, et al. Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation. Science. 2019; 354(6435): eaat8078. - PMC - PubMed
    1. Williams NR, Heifets BD, Blasey C, et al. Attenuation of antagonism effects of ketamine by opioid receptor antagonism. Am J Psychiatry. 2018; 175(12): 1205–1215. - PMC - PubMed
    1. Rorick-Kehn LM, Witcher JW, Lowe SL, et al. Determining pharmacological selectivity of the kappa opioid receptor antagonist LY2456302 using pupillometry as a translational biomarker in rat and human. Int J Neuropsychopharmacology. 2015; 18(2): 1–11. - PMC - PubMed
    1. Zhang K, Hashimoto K. Lack of opioid system in the antidepressant actions of ketamine. Biol Psychiatry. 2019; 85: e25–e27. - PubMed

LinkOut - more resources