Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Mar 24;332(6162):323-7.
doi: 10.1038/332323a0.

Reshaping human antibodies for therapy

L Riechmann  1 , M Clark, H Waldmann, G Winter
Affiliations

Reshaping human antibodies for therapy

L Riechmann et al. Nature. .

Abstract

A human IgGI antibody has been reshaped for serotherapy in humans by introducing the six hypervariable regions from the heavy- and light-chain variable domains of a rat antibody directed against human lymphocytes. The reshaped human antibody is as effective as the rat antibody in complement and is more effective in cell-mediated lysis of human lymphocytes.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources