Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Jul 4;11(7):610.
doi: 10.3390/v11070610.

Progress on the Prevention and Treatment of Hantavirus Disease

Rebecca L Brocato  1 , Jay W Hooper  2
Affiliations
Review

Progress on the Prevention and Treatment of Hantavirus Disease

Rebecca L Brocato et al. Viruses. .

Abstract

Hantaviruses, members of the order Bunyavirales, family Hantaviridae, have a world-wide distribution and are responsible for greater than 150,000 cases of disease per year. The spectrum of disease associated with hantavirus infection include hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS) also known as hantavirus cardiopulmonary syndrome (HCPS). There are currently no FDA-approved vaccines or treatments for these hantavirus diseases. This review provides a summary of the status of vaccine and antiviral treatment efforts including those tested in animal models or human clinical trials.

Keywords: antiviral; hantavirus; hantavirus pulmonary syndrome; hemorrhagic fever with renal syndrome; vaccine.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

References

    1. Elliot R.M., Schmaljohn C.S. Bunyaviridae. In: Knipe D., Howley P., editors. Fields Virology. 6th ed. Volume 1. Lippincott, Williams & Wilkins; Philadelphia, PA, USA: 2013. p. 1244.
    1. Avsic-Zupanc T., Saksida A., Korva M. Hantavirus infections. Clin. Microbiol. Infect. 2019 doi: 10.1111/1469-0691.12291. - DOI - PubMed
    1. Lin X.D., Guo W.P., Wang W., Zou Y., Hao Z.Y., Zhou D.J., Dong X., Qu Y.G., Li M.H., Tian H.F., et al. Migration of norway rats resulted in the worldwide distribution of seoul hantavirus today. J. Virol. 2012;86:972–981. doi: 10.1128/JVI.00725-11. - DOI - PMC - PubMed
    1. Jonsson C.B., Hooper J., Mertz G. Treatment of hantavirus pulmonary syndrome. Antiviral Res. 2008;78:162–169. doi: 10.1016/j.antiviral.2007.10.012. - DOI - PMC - PubMed
    1. Martinez-Valdebenito C., Calvo M., Vial C., Mansilla R., Marco C., Palma R.E., Vial P.A., Valdivieso F., Mertz G., Ferres M. Person-to-person household and nosocomial transmission of andes hantavirus, southern chile, 2011. Emerg. Infect. Dis. 2014;20:1629–1636. doi: 10.3201/eid2010.140353. - DOI - PMC - PubMed

Publication types

MeSH terms