Should I stay or should I go-Reconciling clashing perspectives on CD4⁺ tissue-resident memory T cells

Affiliations

¹ Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, 3000 Melbourne, VIC, Australia. fcarbone@unimelb.edu.au gebhardt@unimelb.edu.au.

Comment

Francis R Carbone et al. Sci Immunol. 2019.

. 2019 Jul 5;4(37):eaax5595.

doi: 10.1126/sciimmunol.aax5595.

¹ Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, 3000 Melbourne, VIC, Australia. fcarbone@unimelb.edu.au gebhardt@unimelb.edu.au.

Abstract

Two recent studies on CD4⁺ T cells in nonlymphoid tissues reveal a combination of memory cell retention and emigration.

CD4⁺ resident memory T cells dominate immunosurveillance and orchestrate local recall responses.
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Human CD4⁺CD103⁺ cutaneous resident memory T cells are found in the circulation of healthy individuals.
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