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Review
. 2019:1910:533-553.
doi: 10.1007/978-1-4939-9074-0_17.

Association Mapping and Disease: Evolutionary Perspectives

Søren Besenbacher  1 , Thomas Mailund  2 , Bjarni J Vilhjálmsson  2 , Mikkel H Schierup  2
Affiliations
Review

Association Mapping and Disease: Evolutionary Perspectives

Søren Besenbacher et al. Methods Mol Biol. 2019.

Abstract

In this chapter, we give a short introduction to the genetics of complex diseases emphasizing evolutionary models for disease genes and the effect of different models on the genetic architecture, and we give a survey of the state-of-the-art of genome-wide association studies (GWASs).

Keywords: Association mapping; Common disease/common variant; Complex diseases; Genome-wide association studies.

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