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. 2019 Aug 30:290:38-41.
doi: 10.1016/j.pscychresns.2019.06.008. Epub 2019 Jul 2.

The resting-brain of obsessive-compulsive disorder

Pedro Silva Moreira  1 , Paulo Marques  2 , Ricardo Magalhães  2 , Madalena Esteves  2 , Nuno Sousa  2 , José Miguel Soares  2 , Pedro Morgado  2
Affiliations

The resting-brain of obsessive-compulsive disorder

Pedro Silva Moreira et al. Psychiatry Res Neuroimaging. .

Abstract

Obsessive-compulsive disorder (OCD) is one of the most debilitating psychiatric conditions, having a dramatic impact on patients' daily living. In this work, we aimed to explore resting-state functional connectivity in OCD patients, using an independent component analysis. Eighty individuals (40 patients and 40 healthy controls) performed a resting state fMRI protocol. OCD patients displayed reduced functional connectivity (FC) in visual and sensorimotor networks. In addition, patients displayed decreased FC between sensory networks and increased FC between default-mode and cerebellar networks.

Keywords: FMRI; Obsessive–compulsive disorder; Resting-state networks.

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