Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Aug:117:103-108.
doi: 10.1016/j.jcv.2019.07.001. Epub 2019 Jul 3.

Clinical manifestations and outcomes of respiratory syncytial virus infection in adult hospitalized patients

Benjamas Chuaychoo  1 , Sopita Ngamwongwan  2 , Bualan Kaewnaphan  3 , Niracha Athipanyasilp  3 , Navin Horthongkham  3 , Wannee Kantakamalakul  3 , Nisa Muangman  4
Affiliations

Clinical manifestations and outcomes of respiratory syncytial virus infection in adult hospitalized patients

Benjamas Chuaychoo et al. J Clin Virol. 2019 Aug.

Abstract

Background: Respiratory syncytial virus (RSV) is an important virus found in adult hospitalized patients.

Objectives: To study the clinical outcomes of hospitalized patients aged ≥ 15 years and diagnosed with RSV infection.

Study design: Both retrospective and prospective cohort studies were conducted at a university hospital between May 2014 and December 2015.

Results: RSV was detected in 86 of 1562(5.5%) adult hospitalized patients suspected of respiratory viral infection. Sixty-nine patients were included in the study. RSV was detected by RT-PCR (82.6%), IFA (10.1%), and both RT-PCR and IFA (7.3%). Most patients (87.0%) were aged ≥ 50 years. Cardiovascular diseases, pulmonary diseases, immunocompromised hosts, and diabetes were the major comorbidities. The common manifestations were cough (92.8%), dyspnea (91.3%), sputum production (87.0%), tachypnea (75.4%), wheezing (73.9%), and fever (71.0%). Fifty- five patients (79.7%) were diagnosed with pneumonia. Hypoxemia (SpO2 ≤ 92%) was found in 53.6% patients. Twenty-five of 69(36.2%) patients developed respiratory failure and required ventilatory support. Cardiovascular complications were found in 24.6% of patients. Congestive heart failure, acute myocardial infarction (MI), new atrial fibrillation, and supraventricular tachycardia were found in 9(13.0%), 7(10.1%), 4(5.8%), and 3(4.3%) of 69 patients, respectively. Overall mortality was 15.9%. Pneumonia (81.8%) and acute MI (18.2%) were the major causes of death.

Conclusions: Most adult hospitalized patients with RSV infection were of advanced age and had comorbidities. Cardiopulmonary complications were the major causes of death. Management and prevention of RSV infection in these vulnerable groups are necessary.

Keywords: Adult; Cardiovascular disease; Hospitalization; Pneumonia; RSV; Respiratory failure.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
All cases (n = 1562) of adult hospitalized patients who sent their respiratory specimens to detect respiratory syncytial virus (RSV). RSV was found in 86 patients (5.5%) over two consecutive rainy seasons.
Fig. 2
Fig. 2
Summary of clinical outcomes in terms of ARI and mortality of community-acquired and nosocomial-acquired RSV infections in adult hospitalized patients. RSV, respiratory syncytial virus; ARI, acute respiratory illness; COPD, chronic obstructive pulmonary disease; HAP, hospital-acquired pneumonia; VAP, ventilator-associated pneumonia.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Borchers A.T., Chang C., Gershwin M.E., Gershwin L.J. Respiratory syncytial virus--a comprehensive review. Clin. Rev. Allergy Immunol. 2013;45(3):331–379. - PMC - PubMed
    1. Hall C.B., Weinberg G.A., Blumkin A.K., Edwards K.M., Staat M.A., Schultz A.F. Respiratory syncytial virus-associated hospitalizations among children less than 24 months of age. Pediatrics. 2013;132(2):e341–8. - PubMed
    1. Naorat S., Chittaganpitch M., Thamthitiwat S., Henchaichon S., Sawatwong P., Srisaengchai P. Hospitalizations for acute lower respiratory tract infection due to respiratory syncytial virus in Thailand, 2008-2011. J. Infect. Dis. 2013;208(Suppl 3):S238–45. - PubMed
    1. Falsey A.R., Hennessey P.A., Formica M.A., Cox C., Walsh E.E. Respiratory syncytial virus infection in elderly and high-risk adults. N. Engl. J. Med. 2005;352(17):1749–1759. - PubMed
    1. Falsey A.R., McElhaney J.E., Beran J., van Essen G.A., Duval X., Esen M. Respiratory syncytial virus and other respiratory viral infections in older adults with moderate to severe influenza-like illness. J. Infect. Dis. 2014;209(12):1873–1881. - PMC - PubMed

MeSH terms