Breast Cancer and Multiple Primary Malignant Tumors: Case Report and Review of the Literature

Abstract

Multiple primary malignant neoplasms are multiple tumors with different pathogenetic origin. They may be synchronous or metachronous. The management of these conditions represents an interesting clinical scenario. A crucial aspect is the decision regarding which tumor to treat initially, and how to schedule further treatments according to individual tumor risk. This process involves a multidisciplinary physician team to ensure favorable outcomes. We describe a case report of a female patient affected by primary synchronous tumors of the breast and pectoral skin, which raised a series of diagnostic, etiological and therapeutic issues persuading us to carry out a critical review of the literature.

Keywords: Breast cancer; multiple primary malignant neoplasms; review; solid tumors.

Figure 1. Ulcerated lesion with necrotic areas of the chest wall involving the skin of the right breast at the moment of the diagnosis.

Figure 2. Breast radiological imaging. a) Mammographic imaging of the right breast at the moment of the diagnosis. b) Ultrasound imaging of the right axillary lymphoadenopathy documented at the moment of the diagnosis.

Figure 3. Breast reconstruction.