Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019;23(2):104-108.
doi: 10.34763/devperiodmed.20192302.104108.

Recent progress in human placental transcriptomics

Marcin Jóźwik  1 , Aleksandra Lipka  1
Affiliations

Recent progress in human placental transcriptomics

Marcin Jóźwik et al. Dev Period Med. 2019.

Abstract

The placenta serves as a metabolic, respiratory, excretory, and endocrine organ that provides appropriate conditions required for adequate fetal development during pregnancy. The development of particular structures and proper functioning of the placenta are under the influence of sophisticated pathways controlled by the expression of substantial genes that are additionally regulated by long non-coding ribonucleic acids (RNAs). Disruptions to adaptive changes in the placental transcriptome as a response to alterations in the feto-maternal environment may be associated with pregnancy complications and compromised fetal outcomes. The aim of the current paper was to present recent findings in transcriptomics of the human placenta. Different approaches in bioinformatic analyses of the RNA-sequencing results were presented. Novel knowledge about the genes and mechanisms that are crucial for the proper development of the placenta is essential for the understanding what stands behind both the normal and complicated pregnancy.

Keywords: humans; placenta; pregnancy complications; transcriptome.

PubMed Disclaimer

Conflict of interest statement

Conflicts of interest:

The Authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Pairwise alignment of examples showing differential splicing events identified in PAPPA and HBA2. Indication is made of the 5' untranslated region (UTR), coding DNA sequence (CDS), and 3' UTR. Adapted from [3].
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Murthi P. Review: Placental homeobox genes and their role in regulating human fetal growth. Placenta. 2014. pp. S46–S50. - DOI - PubMed
    1. Riesgo A, Andrade SC, Sharma PP, Novo M, Perez-Porro AR, Vahtera V, Gonzalez VL, Kawauchi GY, Giribet G. Comparative description of ten transcriptomes of newly sequenced invertebrates and efficiency estimation of genomic sampling in nonmodel taxa. Front Zool. 2012;9(1):33. doi: 10.1186/1742-9994-9-33. - DOI - PMC - PubMed
    1. Majewska M, Lipka A, Paukszto L, Jastrzebski JP, Myszczynski K, Gowkielewicz M, Jozwik M, Majewski MK. Transcriptome profile of the human placenta. Funct Integr Genomics. 2017;17(5):551–563. doi: 10.1007/sl0142-017-0555-y. Sep. - DOI - PMC - PubMed
    1. Majewska M, Lipka A, Panasiewicz G, Gowkielewicz M, Jozwik M, Majewski MK, Szafranska B. Identification of novel placentally expressed aspartic proteinase in humans. Int J Mol Sci. 2017;18(6):1227. doi: 10.3390/ijmsl8061227. - DOI - PMC - PubMed
    1. Majewska M, Lipka A, Paukszto L, Jastrzebski JP, Gowkielewicz M, Jozwik M, Majewski MK. Preliminary RNA-Seq analysis of long non-coding RNAs expressed in human term placenta. Int J Mol Sci. 2018;19(7):1894. doi: 10.3390/ijmsl9071894. - DOI - PMC - PubMed

LinkOut - more resources