Primary prostate lymphoma: A case report and literature review

Abstract

Primary prostate lymphoma (PPL) is rare. This article reports a case of PPL by retrospective analysis of the clinical data and review of the literature, in an attempt to explore the diagnosis, treatment, and prognosis of this rare disease. The present case involves a male patient who came to our hospital for medical consultation of dysuria. Serum prostate-specific antigen (PSA) was not remarkable. Pelvic computed tomography (CT) scan suggested obvious enlargement of the prostate and a tumor in the prostate, but the tumor was not significantly enhanced on contrast-enhanced CT scan. Ultrasound suggested obvious enlargement of the prostate with multiple local low-density echoes and rich blood flow signals inside. Histopathology of prostate biopsy suggested prostate diffuse large B-cell lymphoma (DLBCL). The patient refused chemotherapy but agreed to receive radiotherapy. After radiotherapy, the tumor became smaller and the International Prostate Symptom Score (IPSS) score was reduced. Our experience, together with literature review, suggests that prostate puncture biopsy is an important method for the diagnosis of PPL, and imaging examination can assist the diagnosis. Radiotherapy is able to reduce the tumor volume and relieve the symptoms of urinary tract obstruction, and chemotherapy can help achieve a better therapeutic outcome.

Keywords: diagnosis; lymphoma; prognosis; prostate; treatment.

Figure 1.

(a) Pelvic CT suggests obvious enlargement of the prostate with heterogeneous intensities and stippled calcifications inside; the prostate tumor invades the bilateral seminal vesicles. (b) Contrast-enhanced CT scan shows no obvious enhancement of the tumor.

Figure 2.

Urinary ultrasound suggests obvious enlargement of the prostate that protrudes to the urinary bladder; multiple low-intensity local foci are seen with heterogeneous echoes inside; rich blood flow signals are seen inside the low-intensity foci.

Figure 3.

(a) directions of NHL of the surgery. (b) ELISA tends to suggest large b cell malignant Philippines.

Figure 4.

CT reconstruction suggests that the tumor becomes smaller after radiotherapy as compared with that before radiotherapy.