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Review
. 2019 Jun 10:2019:7315274.
doi: 10.1155/2019/7315274. eCollection 2019.

Neutrophilic Dermatoses and Their Implication in Pathophysiology of Asthma and Other Respiratory Comorbidities: A Narrative Review

Iman Salem  1 , Mark Kimak  1 , Rosalynn Conic  1 , Nicola L Bragazzi  2 , Abdulla Watad  3   4   5 , Mohammad Adawi  6 , Charlie Bridgewood  5 , Alessia Pacifico  7 , Pierachille Santus  8   9 , Maurizio Rizzi  9 , Stephen Petrou  10 , Delia Colombo  11 , Marco Fiore  12 , Paolo D M Pigatto  13   14 , Giovanni Damiani  1   12   13   14   15   16
Affiliations
Review

Neutrophilic Dermatoses and Their Implication in Pathophysiology of Asthma and Other Respiratory Comorbidities: A Narrative Review

Iman Salem et al. Biomed Res Int. .

Abstract

Neutrophilic dermatoses (ND) are a polymorphous group of noncontagious dermatological disorders that share the common histological feature of a sterile cutaneous infiltration of mature neutrophils. Clinical manifestations can vary from nodules, pustules, and bulla to erosions and ulcerations. The etiopathogenesis of neutrophilic dermatoses has continuously evolved. Accumulating genetic, clinical, and histological evidence point to NDs being classified in the spectrum of autoinflammatory conditions. However, unlike the monogenic autoinflammatory syndromes where a clear multiple change in the inflammasome structure/function is demonstrated, NDs display several proinflammatory abnormalities, mainly driven by IL-1, IL-17, and tumor necrosis factor-alpha (TNF-a). Additionally, because of the frequent association with extracutaneous manifestations where neutrophils seem to play a crucial role, it was plausible also to consider NDs as a cutaneous presentation of a systemic neutrophilic condition. Neutrophilic dermatoses are more frequently recognized in association with respiratory disorders than by chance alone. The combination of the two, particularly in the context of their overlapping immune responses mediated primarily by neutrophils, raises the likelihood of a common neutrophilic systemic disease or an aberrant innate immunity disorder. Associated respiratory conditions can serve as a trigger or may develop or be exacerbated secondary to the uncontrolled skin disorder. Physicians should be aware of the possible pulmonary comorbidities and apply this knowledge in the three steps of patients' management, work-up, diagnosis, and treatment. In this review, we attempt to unravel the pathophysiological mechanisms of this association and also present some evidence for the role of targeted therapy in the treatment of both conditions.

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Figures

Figure 1
Figure 1
Hidradenitis suppurativa and its described respiratory comorbidities.
Figure 2
Figure 2
Respiratory comorbidities of pyoderma gangrenosum.
Figure 3
Figure 3
Respiratory manifestations of Sweet syndrome.
Figure 4
Figure 4
Respiratory comorbidities described in the context of pustular psoriasis.
See this image and copyright information in PMC

References

    1. Béal J., Montagud A., Traynard P., Barillot E., Calzone L. Personalization of logical models with multi-omics data allows clinical stratification of patients. Frontiers in Physiology. 2019;9:p. 1965. doi: 10.3389/fphys.2018.01965. - DOI - PMC - PubMed
    1. Deckers J., De Bosscher K., Lambrecht B. N., Hammad H. Interplay between barrier epithelial cells and dendritic cells in allergic sensitization through the lung and the skin. Immunological Reviews. 2017;278(1):131–144. doi: 10.1111/imr.12542. - DOI - PubMed
    1. Erfurt‐Berge C. Influence on contact allergy of immune‐mediated skin diseases such as psoriasis. British Journal of Dermatology. 2018;180(2):256–257. doi: 10.1111/bjd.17413. - DOI - PubMed
    1. DI Meo N., Stinco G., Trevisini S., et al. Pyoderma gangrenosum and burns: a special pathergy phenomenon. Giornale Italiano di Dermatologia e Venereologia. 2017;152:397–400. - PubMed
    1. Leung H. Y. C., Leong P. K., Chen J., Ko K. M. Inter-organ relationships among gut, lung and skin beyond the pathogenesis of allergies: relevance to the Zang-Fu theory in Chinese medicine. Chinese Medicine. 2017;08(03):73–81. doi: 10.4236/cm.2017.83006. - DOI