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. 2019 Jun 1;6(7):ofz263.
doi: 10.1093/ofid/ofz263. eCollection 2019 Jul.

Whole-Genome Sequencing to Differentiate Relapse From Reinfection in Community-Onset Bacteremic Acinetobacter baumannii Pneumonia

Ella M Meumann  1   2 , Nicholas M Anstey  1   2 , Bart J Currie  1   2 , Kim A Piera  1 , Robert Baird  2   3 , Derek S Sarovich  1   4 , Joshua S Davis  1   5
Affiliations

Whole-Genome Sequencing to Differentiate Relapse From Reinfection in Community-Onset Bacteremic Acinetobacter baumannii Pneumonia

Ella M Meumann et al. Open Forum Infect Dis. .

Abstract

Community-onset bacteremic Acinetobacter baumannii pneumonia recurred in 3 of 30 (10%) patients followed prospectively, all with ongoing hazardous alcohol intake, 3-56 months after initial pneumonia. Paired isolates underwent whole-genome sequencing. Phylogenetic analysis showed that recurrence strains were all distinct from preceding strains, indicating reinfection in susceptible individuals rather than relapse.

Keywords: Acinetobacter baumannii; community-acquired pneumonia; recurrence; relapse; whole-genome sequencing.

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Figures

Figure 1.
Figure 1.
Maximum parsimony phylogenetic tree. Strains from the same individual are highlighted in the same color in column 1, with patient and episode number and date of isolation. Bloodstream and sputum isolate pairs are highlighted in column 2, with isolates from the same individual highlighted with the same color. The tree includes 47 additional local A. baumannii strains. Abbreviation: SNP, single nucleotide polymorphism.
See this image and copyright information in PMC

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