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. 2019 Jul;7(7):E885-E892.
doi: 10.1055/a-0895-5377. Epub 2019 Jul 3.

Linked color imaging confers benefits in profiling H. pylori infection in the stomach

Xiaotian Sun  1   2 , Yiliang Bi  1 , Bing Nong  3 , Duanmin Hu  4 , Xiaomin Sun  5 , Honglei Chen  6 , Yang Xu  1 , Yan Liu  1
Affiliations

Linked color imaging confers benefits in profiling H. pylori infection in the stomach

Xiaotian Sun et al. Endosc Int Open. 2019 Jul.

Abstract

Background and study aims There is a high prevalence of Helicobacter pylori infection. White light endoscopy (WLE) can be used for evaluating the mucosal lesions, but it does not have high diagnostic efficiency. Linked color imaging (LCI) is a newly developed endoscopic imaging technique. The aim of this study was to compare LCI with WLE in detecting and staging H. pylori infection in the stomach in a randomized controlled clinical trial. Patients and methods A total of 253 patients who had indications for gastroduodenoscopy were enrolled and randomized into Group A (n = 127), who underwent WLE followed by LCI, and Group B (n = 126), who underwent LCI followed by WLE. Clinical data were collected and the diagnostic accuracy of WLE and LCI was calculated and compared. Results The overall diagnostic accuracy of WLE and LCI for H. pylori infection was 31.5 % (n = 40) and 50.4 % (n = 64) in Group A ( P = 0.001), and 36.5 % (n = 46) and 49.2 % (n = 62) in Group B ( P = 0.029). In both groups, LCI had higher sensitivity, specificity, and Youden index scores than WLE. Four stages were defined in the course of H. pylori infection in the stomach. LCI staging results were more highly consistent with pathological staging than were WLE staging results (kappa value 0.772 vs. 0.516). The LCI observations were closely correlated with the pathology. Conclusion LCI had a higher diagnostic efficacy for H. pylori infection in the stomach. Endoscopic color features under LCI can help to stage and profile H. pylori -associated gastritis.

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Conflict of interest statement

Competing interests None

Figures

Fig. 1
Fig. 1
Typical endoscopic images for H. pylori infection in the stomach.
Fig. 2
Fig. 2
Typical endoscopic images of H. pylori infection-associated gastritis at different stages. In Stage 1, H. pylori infection was observed mainly in the gastric antrum; it can gradually spread into the gastric body in Stage 2. In Stage 3, along with H. pylori -associated inflammation in the mucosa, intestinal metaplasia was found in the antrum. Intestinal metaplasia characterized by presence of goblet cells in the epithelial layer was the main feature of the mucosa of the gastric body in Stage 4; the inflammation can be subtle.
Fig. 3
Fig. 3
LCI findings were closely associated with the pathology.
See this image and copyright information in PMC

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References

    1. Leja M, Axon A, Brenner H. Epidemiology of Helicobacter pylori infection. Helicobacter. 2016;21 01:3–7. - PubMed
    1. OʼConnor A, OʼMorain C A, Ford A C. Population screening and treatment of Helicobacter pylori infection. Nat Rev Gastroenterol Hepatol. 2017;14:230–240. - PubMed
    1. Inoue M. Changing epidemiology of Helicobacter pylori in Japan. Gastric Cancer. 2017;20:3–7. - PubMed
    1. Megraud F, Floch P, Labenz J et al.Diagnostic of Helicobacter pylori infection. Helicobacter. 2016;21 01:8–13. - PubMed
    1. Tongtawee T, Kaewpitoon S, Kaewpitoon N et al.Diagnosis of Helicobacter pylori Infection. Asian Pac J Cancer Prev. 2016;17:1631–1635. - PubMed