Suppression of cytotoxic response to histoincompatible cells. I. Evidence for two types of T lymphocyte-derived suppressors acting at different stages in the induction of a cytotoxic response
- PMID: 312822
Suppression of cytotoxic response to histoincompatible cells. I. Evidence for two types of T lymphocyte-derived suppressors acting at different stages in the induction of a cytotoxic response
Abstract
Spleen and thymus cell populations from normal or allograft tolerant mice have been cultured for 5 days with specific alloantigens and examined for their reactivity in three assay systems. No consistent correlation was observed between the production of cytotoxic T cells (CTL) in these cultures and the ability of such cultured cells to inhibit specifically a CML response from fresh normal spleen cells directed to the priming alloantigens. Furthermore, suppressor cells measured in this latter assay were apparently distinct from those able to inhibit the production of cytotoxic lymphocyte precursors (CTLp) from bone marrow stem cells in lethally irradiated bone marrow protected mice. Velocity sedimentation experiments confirmed that both the precursor and effector cells for the two suppressor systems were physically separable, and were distinct from CTLp or CTL, respectively. Precursor cells for the two suppressor systems investigated belong to the short-lived cortical thymus cell population.
Similar articles
-
Suppression of cytotoxic response to histoincompatible cells. II. Analysis of the role of two independent T suppressor pools in maintenance of neonatally induced allograft tolerance in mice.J Immunol. 1979 Mar;122(3):747-52. J Immunol. 1979. PMID: 312823
-
Differentiation of functionally active mouse T-lymphocytes from functionally inactive bone marrow precursors.Immunology. 1977 Nov;33(5):697-712. Immunology. 1977. PMID: 145406 Free PMC article.
-
Non-H-2-linked genetic regulation of cytotoxic responses to hapten-modified syngeneic cells. I. Non-H-2-linked Ir gene defect expressed on T cells is not predetermined at the stage of bone marrow cells.J Immunol. 1986 Feb 15;136(4):1178-85. J Immunol. 1986. PMID: 2935573
-
Specific, transient suppression of the immune response by HGG tolerant spleen cells. II. Effector cells and target cells.J Immunol. 1976 Oct;117(4):1152-8. J Immunol. 1976. PMID: 61992
-
Impact of thymus on the generation of immunocompetence and diversity of antigen-specific MHC-restricted cytotoxic T-lymphocyte precursors.Immunol Rev. 1981;58:95-129. doi: 10.1111/j.1600-065x.1981.tb00351.x. Immunol Rev. 1981. PMID: 6796497 Review. No abstract available.
Cited by
-
Analysis of neonatally induced tolerance of H-2 alloantigens. II. Failure to detect alloantigen-specific T-lymphocyte precursors and suppressors.Immunogenetics. 1982;15(2):111-27. doi: 10.1007/BF00621945. Immunogenetics. 1982. PMID: 6460693
-
Functional clonal deletion in immunological tolerance to major histocompatibility complex antigens.Proc Natl Acad Sci U S A. 1981 Jun;78(6):3844-7. doi: 10.1073/pnas.78.6.3844. Proc Natl Acad Sci U S A. 1981. PMID: 6455666 Free PMC article.
-
T cell subsets participating in the generation of cytotoxic T cells.Springer Semin Immunopathol. 1980 May;3(1):39-62. doi: 10.1007/BF00199925. Springer Semin Immunopathol. 1980. PMID: 6169168 Review. No abstract available.
-
Inheritance of acquired immunological tolerance to foreign histocompatibility antigens in mice.Proc Natl Acad Sci U S A. 1980 May;77(5):2871-5. doi: 10.1073/pnas.77.5.2871. Proc Natl Acad Sci U S A. 1980. PMID: 6967213 Free PMC article.