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. 2019 Jul 24;141(29):11398-11403.
doi: 10.1021/jacs.9b05363. Epub 2019 Jul 12.

Copper-Catalyzed Decarboxylative Difluoromethylation

Xiaojun Zeng  1 , Wenhao Yan  1 , Samson B Zacate  1 , Tzu-Hsuan Chao  2 , Xiaodong Sun  3   4 , Zhi Cao  3   4 , Kate G E Bradford  1 , Matthew Paeth  1 , Sam B Tyndall  1 , Kundi Yang  1 , Tung-Chun Kuo  2 , Mu-Jeng Cheng  2 , Wei Liu  1
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Copper-Catalyzed Decarboxylative Difluoromethylation

Xiaojun Zeng et al. J Am Chem Soc. .

Abstract

We report herein a highly efficient Cu-catalyzed protocol for the conversion of aliphatic carboxylic acids to the corresponding difluoromethylated analogues. This robust, operationally simple and scalable protocol tolerates a variety of functional groups and can convert a diverse array of acid-containing complex molecules to the alkyl-CF2H products. Mechanistic studies support the involvement of alkyl radicals.

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