Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Jul 19;11(7):610-614.
doi: 10.1093/jmcb/mjz065.

Taking up the reins of power: metabolic functions of p53

Timothy Humpton  1 , Karen H Vousden  2
Affiliations
Review

Taking up the reins of power: metabolic functions of p53

Timothy Humpton et al. J Mol Cell Biol. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
p53 can induce divergent paths to support survival or promote death. Depending on the nature, intensity, and duration of applied stress, p53 engages programs to support cell survival and adaptation or cause death and promote cell elimination. The model suggests that p53 can aid in recovery and repair under conditions of mild and reversible stress, but acts to eliminate cells exposed to persistent stress or irreversible damage. While both responses have the potential to protect from cancer development, inappropriate activation of the death response can promote degenerative diseases or early aging, while inappropriate maintenance of the survival response could help to support malignant development.
See this image and copyright information in PMC

References

    1. Barnoud T., Parris J.L.D., and Murphy M.E. (2019a). Common genetic variants in the TP53 pathway and their impact on cancer. J. Mol. Cell Biol. 11, doi:10.1093/jmcb/mjz052 - DOI - PMC - PubMed
    1. Barnoud T., Parris J.L.D., and Murphy M.E. (2019b). Tumor cells containing the African-centric S47 variant of TP53 show increased Warburg metabolism. Oncotarget 10, 1217–1223. - PMC - PubMed
    1. Beckman G., Birgander R., Sjalander A., et al. (1994). Is p53 polymorphism maintained by natural selection? Hum. Hered. 44, 266–270. - PubMed
    1. Bensaad K., Tsuruta A., Selak M.A., et al. (2006). TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell 126, 107–120. - PubMed
    1. Chen X., Ko L.J., Jayaraman L., et al. (1996). p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells. Genes Dev. 10, 2438–2451. - PubMed

Publication types

MeSH terms

Substances