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Review
. 2019 Sep 15:137:853-869.
doi: 10.1016/j.ijbiomac.2019.07.014. Epub 2019 Jul 5.

Periodate oxidized hyaluronic acid-based hydrogel scaffolds for tissue engineering applications

Ashiq Hussain Pandit  1 , Nasreen Mazumdar  2 , Sharif Ahmad  3
Affiliations
Review

Periodate oxidized hyaluronic acid-based hydrogel scaffolds for tissue engineering applications

Ashiq Hussain Pandit et al. Int J Biol Macromol. .

Abstract

Modification of Hyaluronic acid (HA) with Sodium metaperiodate (NaIO4) results in the formation of oxidized HA (OHA). OHA containing multiple aldehyde groups can easily react with the materials having amino functionality via formation of Schiff base linkage, resulting in the formation of OHA based hydrogel scaffolds. These hydrogels have recently attracted considerable attention as scaffolds for tissue engineering (TE) applications. Thus, the aim of the present review is to give an overview on OHA based hydrogels as scaffolds and their potential application in the field of TE along with the method of synthesis and important properties of OHA.

Keywords: Hyaluronic acid; Hydrogels; Oxidized; Periodate; Scaffolds; Tissue engineering.

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