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. 2019 Nov;12(6):1097-1100.
doi: 10.1111/1751-7915.13460. Epub 2019 Jul 8.

Protective effects of bifidobacteria against enteropathogens

Wanping Aw  1 , Shinji Fukuda  1   2   3   4
Affiliations

Protective effects of bifidobacteria against enteropathogens

Wanping Aw et al. Microb Biotechnol. 2019 Nov.

Abstract

Recent major advances in metagenomics and metabolomics technologies have enabled us to collect more data on the gut microbiome and metabolome to evaluate its influence on host health. In this short opinion article, we have chosen to focus on summarizing the protective mechanisms of bifidobacteria, a highly regarded probiotic, and it's metabolite: acetate; against enteropathogens, specifically in the E. coli O157:H7 mice model. We advocate for using a novel approach metabologenomics, which is an integration of metagenomic and metabolomic information on a systems biology-wide approach to better understand this interplay between gut microbiome and host metabolism.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Mice infected with E. coli O157: H7 associated with bifidobacteria have higher survival rates as some bifidobacterial strains possess an ATP‐binding‐cassette‐type carbohydrate transporter, thereby increasing the production of acetate and inhibited translocation of E. coli O157:H7 produced Shiga toxin from the gut lumen to the blood.
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