Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019;20(14):1447-1460.
doi: 10.2174/1389450120666190708100308.

Circulating and Tissue microRNAs as Biomarkers for Ovarian Cancer Prognosis

Seyed Mostafa Parizadeh  1 , Reza Jafarzadeh-Esfehani  2 , Maryam Ghandehari  1   3 , Malihe Hasanzadeh  4 , Seyed Mohammad Reza Parizadeh  1 , Seyed Mahdi Hassanian  1 , Afsaneh Rezaei-Kalat  5 , Amirsaeed Sabeti Aghabozorgi  6 , Rana Rahimi-Kakhki  1 , Bita Zargaran  1 , Gordon A Ferns  7 , Amir Avan  1   3   8
Affiliations
Review

Circulating and Tissue microRNAs as Biomarkers for Ovarian Cancer Prognosis

Seyed Mostafa Parizadeh et al. Curr Drug Targets. 2019.

Abstract

Ovarian cancer (OC) is one of the most common cancers globally with a high rate of cancer- associated mortality. OC may be classified into epithelial cell neoplasms, germ cell neoplasms and stromal cell neoplasms. The five-year survival in the early and advanced stages of disease is approximately 90% and 15%, respectively. microRNAs are short, single-stranded, non-coding ribonucleic acid (RNA). miRNAs play critical roles in post transcriptionally regulations of gene expression. miRNAs are found in different tissues and body fluids. In carcinogenesis the expression of miRNAs are altered. Recent studies have revealed that there is a relationship between alteration of miRNAs expression and the prognosis of patients with OC. The aim of this review was to summarize the findings of recent studies that have investigated the expression of circulating and tissue miRNAs as novel biomarkers in the prognosis of OC.

Keywords: biomarker; circulating; microRNA; ovarian cancer; prognosis; ribonucleic; tissue..

PubMed Disclaimer