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Review
. 2019 Aug;39(3):391-401.
doi: 10.1016/j.iac.2019.03.007. Epub 2019 May 16.

Beyond Respiratory Syncytial Virus and Rhinovirus in the Pathogenesis and Exacerbation of Asthma: The Role of Metapneumovirus, Bocavirus and Influenza Virus

Andrea M Coverstone  1 , Leyao Wang  2 , Kaharu Sumino  3
Affiliations
Review

Beyond Respiratory Syncytial Virus and Rhinovirus in the Pathogenesis and Exacerbation of Asthma: The Role of Metapneumovirus, Bocavirus and Influenza Virus

Andrea M Coverstone et al. Immunol Allergy Clin North Am. 2019 Aug.

Abstract

Respiratory viruses other than rhinovirus or respiratory syncytial virus, including human metapneumovirus, influenza virus, and human bocavirus, are important pathogens in acute wheezing illness and asthma exacerbations in young children. Whether infection with these viruses in early life is associated with recurrent wheezing and/or asthma is not fully investigated, although there are data to suggest children with human metapneumovirus lower respiratory tract infection may have a higher likelihood of subsequent and recurrent wheezing several years after initial infection.

Keywords: Asthma; Bocavirus; Human metapneumovirus; Influenza virus; Wheezing.

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Figures

Fig. 1
Fig. 1
Survival analysis for wheezing and asthma after hMPV LRTI. Kaplan-Meier estimates of freedom from any wheezing episodes, P = .004; hMPV LRTI subjects had wheezing earlier in follow-up compared with control subjects.
See this image and copyright information in PMC

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References

    1. Allander T., Jartti T., Gupta S., et al. Human bocavirus and acute wheezing in children. Clin Infect Dis. 2007;44(7):904–910. - PMC - PubMed
    1. Heymann P.W., Carper H.T., Murphy D.D., et al. Viral infections in relation to age, atopy, and season of admission among children hospitalized for wheezing. J Allergy Clin Immunol. 2004;114(2):239–247. - PMC - PubMed
    1. Kusel M.M., Kebadze T., Johnston S.L., et al. Febrile respiratory illnesses in infancy and atopy are risk factors for persistent asthma and wheeze. Eur Respir J. 2012;39(4):876–882. - PubMed
    1. Zheng X.Y., Xu Y.J., Guan W.J., et al. Regional, age and respiratory-secretion-specific prevalence of respiratory viruses associated with asthma exacerbation: a literature review. Arch Virol. 2018;163(4):845–853. - PMC - PubMed
    1. Tan W.C. Viruses in asthma exacerbations. Curr Opin Pulm Med. 2005;11(1):21–26. - PubMed