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. 1988 Jan;79(1):49-58.
doi: 10.1111/j.1349-7006.1988.tb00010.x.

Hepatocellular tumorigenicity of butylated hydroxytoluene administered orally to B6C3F1 mice

K Inai  1 , T Kobuke, S Nambu, T Takemoto, E Kou, H Nishina, M Fujihara, S Yonehara, S Suehiro, T Tsuya, et al.
Affiliations

Hepatocellular tumorigenicity of butylated hydroxytoluene administered orally to B6C3F1 mice

K Inai et al. Jpn J Cancer Res. 1988 Jan.

Abstract

Butylated hydroxytoluene (BHT), a preservative widely found in food as a food additive, was orally administered at concentrations of 1% and 2% of the diet to B6C3F1 mice for 104 consecutive weeks. Treated animals underwent a 16-week recovery period prior to pathological examination. In male mice administered BHT, the incidence of mice with either a hepatocellular adenoma or a focus of cellular alteration in the liver was increased in a clear dose-response relationship. The incidences of male mice with other tumors and the incidences of female mice with any tumor were not significantly increased as a consequence of BHT administration. The results of this study indicate BHT to be tumorigenic to the liver of the B6C3F1 male mouse.

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References

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