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. 2019 Jun 26;5(6):FSO397.
doi: 10.2144/fsoa-2019-0038.

Glycemic control and survival of patients with coexisting diabetes mellitus and gastric or esophageal cancer

Nina J Karlin  1 , Matthew R Buras  2 , Heidi E Kosiorek  2 , Patricia M Verona  3 , Curtiss B Cook  4
Affiliations

Glycemic control and survival of patients with coexisting diabetes mellitus and gastric or esophageal cancer

Nina J Karlin et al. Future Sci OA. .

Abstract

Aim: To examine effects of diabetes mellitus (DM) on survival in gastric or esophageal (GE) cancer and the cancers' effects on glycemic control.

Materials & methods: Patients with GE cancer with and without DM were matched 1 to 1 (2006-2016). Characteristics were compared and survival assessed with Kaplan-Meier method and Cox regression. Mixed models compared hemoglobin A1c and glucose over time.

Results: Among DM cases, mean hemoglobin A1c was 6.8% in the year after cancer diagnosis. Three-year overall survival was 46% with DM versus 52% without DM (hazard ratio [95% CI]: 1.95 [1.14-3.34]; p = 0.02).

Conclusion: GE cancer and its treatment did not affect glycemic control. Risks of death and progression were greater for patients with DM than patients without DM.

Keywords: cancer; endocrinology; glycemia; malignancy; mortality; outcomes research.

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Conflict of interest statement

Financial & competing interests disclosure The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. No writing assistance was utilized in the production of this manuscript.

Figures

Figure 1.
Figure 1.. Values measured over the first year after gastric or esophageal cancer diagnosis.
(A) HbA1c percentages of patients with DM. (B) Comparison of glucose concentrations of patients with DM vs no DM. DM: Diabetes mellitus; GE: Gastric or esophageal; HbA1c: Hemoglobin A1c.
Figure 2.
Figure 2.. Overall survival of patients with and without diabetes mellitus.
DM: Diabetes mellitus.
Figure 3.
Figure 3.. Progression-free survival of patients with and without diabetes mellitus.
DM: Diabetes mellitus.
See this image and copyright information in PMC

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