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Meta-Analysis
. 2019 Jul 8;19(1):84.
doi: 10.1186/s12893-019-0540-6.

The value of combined vein resection in pancreaticoduodenectomy for pancreatic head carcinoma: a meta-analysis

Cheng Peng  1 , Di Zhou  2 , Lingjun Meng  2 , Yanlong Cao  3 , Hanwen Zhang  1 , Zheng Pan  1 , Chao Lin  4
Affiliations
Meta-Analysis

The value of combined vein resection in pancreaticoduodenectomy for pancreatic head carcinoma: a meta-analysis

Cheng Peng et al. BMC Surg. .

Abstract

Background: Although pancreaticoduodenectomy with vein resection (PDVR) is widely performed in selected patients with indications, its benefits remain controversial. In this meta-analysis, we evaluate the safety and efficacy of PDVR in comparison to standard pancreaticoduodenectomy (PD).

Methods: We searched PubMed, Embase, and Cochrane as well as the Chinese National Knowledge Infrastructure, Weipu, and Wanfang databases for studies that evaluate the value of PVDR. The data of the patients who underwent PD or PDVR were analyzed using Review Manager and STATA software.

Results: In comparison with the PD group, the PDVR group had a lower R0 resection rate and higher rates of complications such as biliary fistula, reoperation rate, delayed gastric emptying, cardiopulmonary abnormalities, hemorrhage, in-hospital mortality, 30-day mortality. The blood loss, duration of operation, total hospital stay is higher in PDVR group.

Conclusions: Compared to standard PD, PDVR was associated with a greater risk of some specific complications and increase the mortality rate, total hospital stay time, combine with vein resection have a lower R0 resection rate. Therefore, combine with vascular resection for pancreatic cancer needs to be carefully selected by the surgeon.

Keywords: Meta-analysis; Pancreatic cancer; Pancreaticoduodenectomy; Vein resection.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Flow diagram of the studies identified in the meta-analysis
Fig. 2
Fig. 2
Comparison of PDVR and PD by surgical procedures and hospitalization
Fig. 3
Fig. 3
Comparison of PDVR and PD by mortality
Fig. 4
Fig. 4
Comparison of PDVR and PD by oncological outcome
Fig. 5
Fig. 5
Comparison of PDVR and PD by postoperative complications
Fig. 6
Fig. 6
Funnel plots for publication bias assessment
See this image and copyright information in PMC

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