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. 2019 Dec;60(14):3426-3433.
doi: 10.1080/10428194.2019.1639166. Epub 2019 Jul 9.

Clinical features and survival of patients with T-cell/histiocyte-rich large B-cell lymphoma: analysis of the National Cancer Data Base

Thomas A Ollila  1   2 , John L Reagan  1   2 , Adam J Olszewski  1   2
Affiliations

Clinical features and survival of patients with T-cell/histiocyte-rich large B-cell lymphoma: analysis of the National Cancer Data Base

Thomas A Ollila et al. Leuk Lymphoma. 2019 Dec.

Abstract

Using data from the National Cancer Data Base, 2010-2015, we examined characteristics and outcomes of T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL, N = 622) relative to unspecified diffuse large B-cell lymphoma (DLBCL-NOS, N = 91,588) and nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL, N = 2240). Socio-demographic characteristics of patients with THRLBCL resembled more NLPHL than DLBCL-NOS. Five-year overall survival in THRLBCL was 66% (95% confidence interval [CI], 60-71%). Adjusting for clinical and socio-economic covariates, THRLBCL was associated with better survival than DLBCL-NOS (adjusted hazard ratio, 0.80; 95%CI, 0.67-0.94). This association was similar in academic and community hospitals and consistent in a model stratified by the revised International Prognostic Index. Prognostic factors in THRLBCL included age, comorbidity index, and extranodal primary site, but not stage. Adjusted odds of prior NLPHL were 18.2 higher for THRLBCL (95%CI, 7.2-45.7) than DLBCL-NOS. These large-scale epidemiologic data support the relationship between THRLBCL and NLPHL, and suggest improved prognosis with modern rituximab-based immunochemotherapy.

Keywords: Diffuse large B-cell lymphoma; T-cell/histiocyte-rich large B-cell lymphoma; epidemiology; nodular lymphocyte predominant Hodgkin lymphoma; survival analysis.

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Conflict of interest statement

Disclosure of interest

T.A.O. reports no conflict of interest; A.J.O. reports research funding from Genentech and Spectrum Pharmaceuticals; J.L.R. reports consultancy for Teva.

Figures

Fig. 1.
Fig. 1.
(A) Overall survival of patients with THRLBCL, DLBCL-NOS, and NLPHL; (B) overall survival in THRLBCL, compared with DLBCL-NOS matched by age, sex, race, stage, presence of B symptoms, extranodal site, comorbidity index, income, and type of treating hospital.
Fig. 2.
Fig. 2.
Overall survival of patients with THRLBCL, stratified by (A) type of reporting hospital, (B) stage, and (C) nodal/extranodal primary site.
See this image and copyright information in PMC

References

    1. Swerdlow SH, World Health Organization, International Agency for Research on Cancer WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon: International Agency for Research on Cancer; 2017. 585 pages p.
    1. Pittaluga S, Jaffe ES. T-cell/histiocyte-rich large B-cell lymphoma. Haematologica 2010; 95: 352–356. - PMC - PubMed
    1. Achten R, Verhoef G, Vanuytsel L, et al. T-cell/histiocyte-rich large B-cell lymphoma: a distinct clinicopathologic entity. J Clin Oncol 2002; 20: 1269–1277. - PubMed
    1. El Weshi A, Akhtar S, Mourad WA, et al. T-cell/histiocyte-rich B-cell lymphoma: Clinical presentation, management and prognostic factors: report on 61 patients and review of literature. Leuk Lymphoma 2007; 48: 1764–1773. - PubMed
    1. Bouabdallah R, Mounier N, Guettier C, et al. T-cell/histiocyte-rich large B-cell lymphomas and classical diffuse large B-cell lymphomas have similar outcome after chemotherapy: a matched-control analysis. J Clin Oncol 2003; 21: 1271–1277. - PubMed

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