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Comparative Study
. 1978 Nov 1;52(1):125-8.
doi: 10.1016/0014-2999(78)90030-4.

Stimulation of arachidonic acid metabolism by human slow-reacting substances

J P Seale, P J Piper
Comparative Study

Stimulation of arachidonic acid metabolism by human slow-reacting substances

J P Seale et al. Eur J Pharmacol. .

Abstract

Human slow-reacting substance of anaphylaxis (SRS-A) and calcium ionophore-induced human SRS released prostaglandin-like substances and rabbit aorta contracting substance (RCS) from guinea-pig lungs. This effect was abolished by incubation of SRS-A and SRS with arylsulphatase or pretreatment of the lungs with indomethacin. Human SRS-A and SRS therefore resembled guinea-pig SRS-A in stimulating arachidonic acid metabolism. These results provide further evidence for a similar (or identical) nature of human SRS-A and SRS and suggest a possible role for slow-reacting substances in the release of prostaglandins during anaphylaxis.

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