The search for meaning in preclinical Alzheimer disease clinical trials

Affiliations

¹ From the Department of Family Medicine (S.D.H.), University of Southern California, Alhambra; Department of Neurology (S.D.H.), Department of Psychology (S.D.H.), and School of Gerontology (S.D.H.), University of Southern California, Los Angeles; and Neurology Clinic Chiba (H.S.), Chiba City, Chiba, Japan. Duke.Han@med.usc.edu.
² From the Department of Family Medicine (S.D.H.), University of Southern California, Alhambra; Department of Neurology (S.D.H.), Department of Psychology (S.D.H.), and School of Gerontology (S.D.H.), University of Southern California, Los Angeles; and Neurology Clinic Chiba (H.S.), Chiba City, Chiba, Japan.

Editorial

S Duke Han et al. Neurology. 2019.

. 2019 Jul 23;93(4):139-140.

doi: 10.1212/WNL.0000000000007817. Epub 2019 Jul 9.

¹ From the Department of Family Medicine (S.D.H.), University of Southern California, Alhambra; Department of Neurology (S.D.H.), Department of Psychology (S.D.H.), and School of Gerontology (S.D.H.), University of Southern California, Los Angeles; and Neurology Clinic Chiba (H.S.), Chiba City, Chiba, Japan. Duke.Han@med.usc.edu.
² From the Department of Family Medicine (S.D.H.), University of Southern California, Alhambra; Department of Neurology (S.D.H.), Department of Psychology (S.D.H.), and School of Gerontology (S.D.H.), University of Southern California, Los Angeles; and Neurology Clinic Chiba (H.S.), Chiba City, Chiba, Japan.

No abstract available

Comment on

Determining clinically meaningful decline in preclinical Alzheimer disease.
Insel PS, Weiner M, Mackin RS, Mormino E, Lim YY, Stomrud E, Palmqvist S, Masters CL, Maruff PT, Hansson O, Mattsson N. Insel PS, et al. Neurology. 2019 Jul 23;93(4):e322-e333. doi: 10.1212/WNL.0000000000007831. Epub 2019 Jul 9. Neurology. 2019. PMID: 31289148 Free PMC article.

Building clinically relevant outcomes across the Alzheimer's disease spectrum.
Rentz DM, Wessels AM, Annapragada AV, Berger AK, Edgar CJ, Gold M, Miller DS, Randolph C, Ryan JM, Wunderlich G, Zoschg MC, Trépel D, Knopman DS, Staffaroni AM, Bain LJ, Carrillo MC, Weber CJ. Rentz DM, et al. Alzheimers Dement (N Y). 2021 Jun 26;7(1):e12181. doi: 10.1002/trc2.12181. eCollection 2021. Alzheimers Dement (N Y). 2021. PMID: 34195350 Free PMC article.